26592-16-5Relevant academic research and scientific papers
Simple phase transfer catalytic method for α-methoxylation of sterically hindered ketones
Abele,Rubina,Shymanska,Lukevics
, p. 1371 - 1376 (2007/10/02)
Reactions of sterically hindered ketones of ArylCOCHR1R2 type (R1, R2 = Me, Et, Ph) with carbon tetrachloride and methyl iodide in the presence of solid KOH and 18-crown-6 afford the corresponding α-methoxyketones [ArylCOC(OMe)R1R2] in one-pot process in 30-67% yields.
Quasi-template Effect: a Tool for Controlling Stereochemistry in Acyclic Systems. Attempted Stereoselective Synthesis of α,α'-Dimethoxystilbene
Inoue, Yoshihisa,Ikeda, Hirokazu,Hakushi, Tadao
, p. 259 - 262 (2007/10/02)
Alkylation with methyl tosylate of stilbenediol dianion, prepared in the reaction of benzoin with a series of alkali-metal hydroxides in THF, gave (E)- and (Z)-α,α'-dimethoxystilbenes as the major products in most cases, the E:Z ratio of which varies from 0.4 to 5.0 depending upon the alkali-metal cation employed; the results are rationalized in the quasi-template effect in an acyclic system and the hard-soft ion principle.
