26697-34-7

Basic information

• Product Name: 4-BENZYLOXY-2-NITROACETANILIDE)
• Synonyms: 4-BENZYLOXY-2-NITROACETANILIDE)
• CAS NO: 26697-34-7
• Molecular Formula: C₁₅H₁₄N₂O₄
• Molecular Weight: 286.28266
• Mol File: 26697-34-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 523.5°Cat760mmHg
• Flash Point: 270.4°C
• Appearance: /
• Density: 1.306g/cm³
• Vapor Pressure: 4.68E-11mmHg at 25°C
• Refractive Index: 1.632
• CAS DataBase Reference: 4-BENZYLOXY-2-NITROACETANILIDE)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BENZYLOXY-2-NITROACETANILIDE)(26697-34-7)
• EPA Substance Registry System: 4-BENZYLOXY-2-NITROACETANILIDE)(26697-34-7)

Safety Data

• Hazardous Substances Data: 26697-34-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H14N2O4/c1-11(18)16-14-8-7-13(9-15(14)17(19)20)21-10-12-5-3-2-4-6-12/h2-9H,10H2,1H3,(H,16,18)

Upstream product

• 41927-14-4 N-[4-(benzyloxy)phenyl]acetamide 
• 103-84-4 Acetanilid 
• 100-51-6 benzyl alcohol 
• 100-44-7 benzyl chloride 
• 103-90-2 4-acetaminophenol 
• 7403-75-0 N-(4-hydroxy-2-nitrophenyl)-acetamide 
• 100-39-0 benzyl bromide 

Downstream Products

• 142646-11-5 C₁₇H₁₇N₃O₅S 
• 142646-10-4 N-methoxycarbonyl-N'-(4-benzyloxy-2-nitrophenyl)thiourea 
• 54029-21-9 (6-benzyloxy-1H-benzimidazol-2-yl)carbamic acid methyl ester 
• 26697-35-8 4-benzyloxy-2-nitroaniline 

Relevant articles and documents

Acylamino-Directed Specific Sequential Difunctionalizations of Anilides via Metal-Free Relay Reactions for p-Oxygen and o-Nitrogen Incorporation

Novel acylamino-directed relay disubstitutions realize the sequential difunctionalizations of anilides (1) under mild and metal-free conditions for the first time. This [bis(trifluoroacetoxy)iodo]benzene (PIFA) and BF3·Et2O promoted straightforward reaction produces a series of p-acetoxyl- or p-alkoxyl-o-nitro-N-arylamides (2), which are key scaffolds of various drugs, functional materials, and bioactive molecules. The flexibility with respect to the functional groups in these products affords this novel protocol excellent versatility for synthetic applications.

Functionalized alkoxy arene diazonium salts from paracetamol

Arene diazonium tetrafluoroborates can be synthesized from aromatic acetamides via a sequence of deacetylation, diazotation and precipitation, induced by anion exchange. The reaction is conducted as a convenient one-flask transformation with consecutive addition of the appropriate reagents. Exchange of solvents or removal of byproducts prior to isolation of the product is not required. The arene diazonium salts are isolated from the reaction mixture by simple filtration. Two complementary protocols are presented, and the utility of the reaction is exemplified for a synthesis of the diarylheptanoid natural product de-O-methyl centrolobine.

5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity

Carbalkoxythioureidobenzene derivatives represented by the following formula: STR1 where R is a lower alkyl group having 1 to 4 carbon atoms; R1 is --SR2, --SOR2, --SO2 R2, --OR2, --SCN, --SC(O)NR3 R4, or --M'(CH2)n MR7 where n is 1-4; R2 is lower alkyl having 1 to 6 carbon atoms, cycloalkyl having 3 to 7 carbon atoms, lower alkenyl or lower alkynyl having 3 to 6 carbon atoms, aralkyl or aryl, provided that when R1 is --SO2 R2, R2 is not aralkyl or phenyl; R3 and R4 are independently hydrogen or lower alkyl having 1 to 6 carbon atoms; Y is amino, nitro, acylamino where the acyl portion has 1 to 6 carbon atoms, --NHC(O) (CH2)m COOH where m is 1-6, or --NHC(S)NHCOOR; M and M' are independently O, S or STR2 and R7 is lower alkyl having 1 to 4 carbon atoms or aryl. The R1 substitution is either at the 4- or 5-position. The compounds are useful as pesticides, particularly as anthelmintic and antifungal agents.