7403-75-0

Basic information

• Product Name: 3-NITRO-4-ACETAMIDOPHENOL
• Synonyms: 3-NITRO-4-ACETAMIDOPHENOL;1-AcetaMido-4-hydroxy-2-nitrobenzene;4-AcetaMido-3-nitrophenol;4'-Hydroxy-2'-nitroacetanilide;N-(4-Hydroxy-2-nitrophenyl)acetaMide;NSC 400387
• CAS NO: 7403-75-0
• Molecular Formula: C₈H₈N₂O₄
• Molecular Weight: 196.16012
• Product Categories: Aromatics Compounds;Aromatics
• Mol File: 7403-75-0.mol
• Article Data: 8

Chemical Properties

• Melting Point: 218-220°C
• Boiling Point: 459.1°Cat760mmHg
• Flash Point: 231.5°C
• Appearance: /
• Density: 1.477g/cm³
• Vapor Pressure: 4.74E-09mmHg at 25°C
• Refractive Index: 1.658
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 8.23±0.12(Predicted)
• CAS DataBase Reference: 3-NITRO-4-ACETAMIDOPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-NITRO-4-ACETAMIDOPHENOL(7403-75-0)
• EPA Substance Registry System: 3-NITRO-4-ACETAMIDOPHENOL(7403-75-0)

Safety Data

• Hazardous Substances Data: 7403-75-0(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

3-Nitro-4-acetamidophenol (cas# 7403-75-0) is a compound useful in organic synthesis.

InChI:InChI=1/C8H8N2O4/c1-5(11)9-7-3-2-6(12)4-8(7)10(13)14/h2-4,12H,1H3,(H,9,11)

Upstream product

• 103-84-4 Acetanilid 
• 103-90-2 4-acetaminophenol 
• 2623-33-8 4-acetoxyacetanilide 
• 2243-69-8 4-acetamido-3-nitrophenyl acetate 
• 7726-95-6 bromine 
• 64-19-7 acetic acid 
• 7664-93-9 sulfuric acid 
• 50700-49-7 N-acetyl-p-benzoquinoneimine 
• 610-81-1 4-hydroxy-2-nitroaniline 
• 108-24-7 acetic anhydride 

Downstream Products

• 105906-40-9 acetic acid-[4-(3-bromo-propoxy)-2-nitro-anilide] 
• 111992-31-5 1,3-bis-(4-acetylamino-3-nitro-phenoxy)-propane 
• 99233-28-0 4-acetamino-2,3-dinitrophenol 
• 871878-62-5 acetic acid-(4-hydroxy-2,5-dinitro-anilide) 
• 875923-68-5 N-[4-(6-chlorohexyloxy)-2-nitrophenyl]acetamide 
• 875923-67-4 N-[4-(5-chloropentyloxy)-2-nitrophenyl]acetamide 
• 808747-08-2 ethyl 4-[4-(acetylamino)-3-nitrophenoxy]-2,2-dimethylbutanoate 
• 875923-71-0 2-nitro-4-(6-piperidin-1-ylhexyloxy)phenylamine 
• 917225-22-0 N-{4-[5-(4-chlorophenoxy)pentyloxy]-2-nitrophenyl}acetamide 
• 917225-14-0 N-{4-[4-(4-chlorophenoxy)butoxy]-2-nitrophenyl}acetamide 
• 875923-74-3 4-[5-(4-chlorophenoxy)pentyloxy]-2-nitrophenylamine 
• 917224-84-1 N-{4-[3-(4-chlorophenoxy)propoxy]-2-nitrophenyl}acetamide 
• 875923-70-9 2-nitro-4-(5-piperidin-1-ylpentyloxy)phenylamine 

Relevant articles and documents

Acylamino-Directed Specific Sequential Difunctionalizations of Anilides via Metal-Free Relay Reactions for p-Oxygen and o-Nitrogen Incorporation

Novel acylamino-directed relay disubstitutions realize the sequential difunctionalizations of anilides (1) under mild and metal-free conditions for the first time. This [bis(trifluoroacetoxy)iodo]benzene (PIFA) and BF3·Et2O promoted straightforward reaction produces a series of p-acetoxyl- or p-alkoxyl-o-nitro-N-arylamides (2), which are key scaffolds of various drugs, functional materials, and bioactive molecules. The flexibility with respect to the functional groups in these products affords this novel protocol excellent versatility for synthetic applications.

Regioselective Green Electrochemical Approach to the Synthesis of Nitroacetaminophen Derivatives

A regioselective green synthesis of nitroacetaminophen derivatives was carried out by electrochemical oxidation of acetaminophen, N-(2-hydroxyphenyl)acetamide, and 1-(4-(4-hydroxyphenyl)piperazin-1-yl)ethanone in the presence of nitrite ion as a nucleophile. The present work has led to the development of a reagentless green and facile electrochemical method for the synthesis of some nitroacetaminophen derivatives.

Reductive cyclization with baker's yeast of 4-alkyl-2-nitro-acetanilides to 6-alkylbenzimidazoles and 1-hydroxy-2-methyl-6-alkylbenzimidazoles

Reduction of 4-substituted 2-nitroacetanilides by baker's yeast in acid media effected cyclization, resulting in the formation of n-substituted 2-methylbenzimidazoles and 6-substituted 1-hydroxy-2-methylbenzimidazole via the chemo- and regioselective reduction of the 2-nitro aromatic group to amine or hydroxylamine.