26889-08-7

Upstream product

• 127531-09-3 (S)-3-Cyano-2-[(1R,2R,5R)-2-hydroxy-2,6,6-trimethyl-bicyclo[3.1.1]hept-(3E)-ylideneamino]-propionic acid ethyl ester 
• 34404-27-8 N^α,N^γ-bis(t-butoxycarbonyl)-L-α,γ-butyric acid 
• 103668-08-2 (R)-2,4-Diamino-butyric acid ethyl ester; hydrochloride 

Downstream Products

• 97347-23-4 N^α,N^γ-diBoc-L-2,4-diaminobutyric acid p-nitrobenzyl ester 
• 126581-98-4 DPAB-L-DBA (trans) 
• 25139-87-1 ⁽⁵⁾-(+)(D)-N,N'-Ditosyl-2,4-diamino-butanol 
• 4128-00-1 (3S)-3-aminopyrrolidin-2-one 
• 1217645-10-7 (R)-2,4-bis((((9H-fluoren-9-yl)methoxy)carbonyl)amino)butanoic acid 
• 55478-23-4 (S)-2,4-bis(((benzyloxy)carbonyl)amino)butanoic acid 
• 117106-22-6 (S)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-aminobutanoic acid 

Relevant academic research and scientific papers

Preparation of enantiopure 2-acylazetidines and their reactions with chloroformates

Enantiopure 1-phenylethylazetidine-2-carboxylates and 2-acylazetidines were prepared and reacted with chloroformates to yield α-chloro-γ-amino butyric acid esters and ketones from ring opening reaction of azetidinium ion intermediate in a completely regio- and stereoselective manner.

ENANTIOSELECTIVE SYNTHESIS OF OPTICALLY PURE NATURAL S(+) OR UNNATURAL R(-) DABA

After optimization of the reaction conditions, optically pure S(+) DABA is obtained in more than 80percent overall yield.A modell is proposed to explain the dependence of asymmetric induction on the nature of the counter ion (Li(1+), Mg(2+), Bu4N(1+)).