26974-09-4

Basic information

• Product Name: 2-AMINO-4-PHENYL-6-(TRIFLUOROMETHYL)PYRIMIDINE
• Synonyms: AKOS BBS-00000387;4-PHENYL-6-(TRIFLUOROMETHYL)-2-PYRIMIDINYLAMINE;4-PHENYL-6-(TRIFLUOROMETHYL)PYRIMIDIN-2-AMINE;4-(TRIFLUOROMETHYL)-6-PHENYLPYRIMIDIN-2-AMINE;2-AMINO-4-PHENYL-6-(TRIFLUOROMETHYL)PYRIMIDINE;2-Amino-4-phenyl-6-(trifluoromethyl)pyrimidine 97%;2-Amino-4-phenyl-6-(trifluoromethyl)pyrimidine97%;2-Amino-4-phenyl-6-(trifluoromethyl)pyrimidne
• CAS NO: 26974-09-4
• Molecular Formula: C₁₁H₈F₃N₃
• Molecular Weight: 239.2
• Mol File: 26974-09-4.mol
• Article Data: 8

Chemical Properties

• Melting Point: 131-133
• Boiling Point: 397.5 °C at 760 mmHg
• Flash Point: 194.2 °C
• Appearance: /
• Density: 1.351 g/cm³
• Vapor Pressure: 0.005mmHg at 25°C
• Refractive Index: 1.524
• CAS DataBase Reference: 2-AMINO-4-PHENYL-6-(TRIFLUOROMETHYL)PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-4-PHENYL-6-(TRIFLUOROMETHYL)PYRIMIDINE(26974-09-4)
• EPA Substance Registry System: 2-AMINO-4-PHENYL-6-(TRIFLUOROMETHYL)PYRIMIDINE(26974-09-4)

Safety Data

• Hazard Codes: Xi,T
• Statements: 36/37/38-25
• Safety Statements: 26-36/37/39-45-24/25
• Hazardous Substances Data: 26974-09-4(Hazardous Substances Data)

Usage

Chemical Properties

White to light yellow solid

InChI:InChI=1/C10BrF7/c11-3-4(12)1-2(5(13)8(3)16)7(15)10(18)9(17)6(1)14

Upstream product

• 149846-93-5 1-phenyl-4,4,4-trifluorobut-2-yn-1-ol 
• 85694-32-2 1-phenyl-4,4,4-trifluoro-1-butyn-3-one 
• 50-01-1 guanidine hydrochloride 
• 593-85-1 guanidine carbonate 
• 58518-08-4 1,1,1-trifluoro-4-phenylbut-3-yn-2-one 
• 326-06-7 1-Phenyl-4,4,4-trifluorobutane-1,3-dione 
• 98-86-2 acetophenone 
• 6048-29-9 triphenylphenacylphosphonium bromide 
• 1020540-98-0 4-trifluoromethyl-6-phenyl-2-acetylaminopyrimidine 
• 536-74-3 phenylacetylene 
• 113-00-8 guanidine nitrate 
• 593-85-1 diguanidine carbonate 
• 172032-06-3 1,1,1,2,2-pentafluoro-4-iodo-4-phenyl-3-butene 
• 594-14-9 guanidinium sulfate 

Relevant articles and documents

Fluorinated β-diketo phosphorus ylides: Their cyclocondensation with amidines affording 4-trifluoromethyl- And 4-perfluoroalkyl-substituted pyrimidines

A study is presented for the syntheses of a series of 4-trifluoromethyl- and 4-perfluoroalkyl-substituted pyrimidines from the reaction of trifluoromethyl or perfluoroalkyl β-diketo phosphorus ylides (Ph3P=C(CORF)COR) with amidine hydrochloride.

One-Pot, Atom and Step Economy (PASE) Assembly of Trifluoromethylated Pyrimidines from CF3-Ynones

A highly efficient synthetic method for the preparation of of 6-trifluoromethylated pyrimidines was developed. The reaction of CF3-substituted ynones and nitrogen 1,3-bis(nucleophile)s was employed for the one-pot assembly of the pyrimidine core. The cascade route proceeded through an aza-Michael addition, intramolecular cyclization, and dehydration reaction sequence to give the target heterocycles in excellent yields (up to 97 %). When acetamidine was used as the bis(nucleophile), the unexpected addition of two equivalents of the CF3-substituted ynone to the acetamidine was observed.

One-pot synthesis of N2-aminoprotected 6-substituted and cycloalka[d] 4-trifluoromethyl-2-acetylaminopyrimidines

(Chemical Equation Presented) The one-pot synthesis of a novel series of amino-protected 6-alkyl-, 6-aryl-, 6-heteroaryl- and 5,6-fused-cycloalkane 4-trifluoromethyl-2-acetylaminopyrimidines, where alkyl = Me; aryl = Ph, 4-CH3Ph, 4-FPh, 4-ClPh, 4-BrPh, 4-OCH3Ph, 4-NO 2Ph, 4,4′-biphenyl, 1-naphthyl; heteroaryl = 2-thienyl, 2-furyl and cycloalkyl = c-C6H4, c-C7H5 from the reaction of substituted 4-methoxy-1,1,1-trifluoroalk-3-en-2-ones with 1-acetylguanidine in acetonitrile or propan-2-ol as solvent, is reported. The acetylamino group of 2-acetylaminopyrimidines was hydrolyzed under three different conditions to afford the corresponding free 2-aminopyrimidines.