66999-50-6 Usage
General Description
Nsc289801, also known as VX-809, is a small molecule chemical compound that has shown potential for the treatment of cystic fibrosis. It is a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, which is defective in individuals with cystic fibrosis. Nsc289801 has been found to improve the processing and trafficking of the CFTR protein to the cell surface, ultimately leading to improved chloride transport and mucus clearance in the lungs. Nsc289801 has shown promise in preclinical and clinical studies, with the potential to improve the quality of life for individuals with cystic fibrosis by addressing the underlying cause of the disease at a molecular level.
Check Digit Verification of cas no
The CAS Registry Mumber 66999-50-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,9,9 and 9 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 66999-50:
(7*6)+(6*6)+(5*9)+(4*9)+(3*9)+(2*5)+(1*0)=196
196 % 10 = 6
So 66999-50-6 is a valid CAS Registry Number.
66999-50-6Relevant articles and documents
Synthesis and studies on the anticonvulsant activity of 5-alkoxy-[1,2,4]triazolo[4,3-a]pyridine derivatives
Guan,Zhang,Sun,Chang,Sui
, p. 372 - 377 (2012/10/29)
In this study, a series of new 5-alkoxy-[1,2,4]triazolo[4,3-a]pyridine derivatives was synthesized and their anticonvulsant activity and neurotoxicity was evaluated with the maximal electroshock and rotarod tests, respectively. The most promising compounds, 3p (5-(4-chlorophenoxy)-[1,2,4]triazolo[4,3-a] pyridine) and 3r (5-(4-bromophenoxy)-[1,2,4]triazolo[4,3-a]pyridine), showed a median effective dose of 13.2 and 15.8 mg/kg and had a protective index value of 4.8 and 6.9, respectively. For exploring the putative mechanism of action, compounds 3n, 3p and 3r were tested in chemically induced models. Georg Thieme Verlag KG Stuttgart.New York.
