27293-29-4Relevant academic research and scientific papers
Synthesis, antimycobacterial, antiviral, antimicrobial activity and QSAR studies of N2-acyl isonicotinic acid hydrazide derivatives
Judge, Vikramjeet,Narasimhan, Balasubramanian,Ahuja, Munish,Sriram, Dharmarajan,Yogeeswari, Perumal,De Clercq, Erik,Pannecouque, Christophe,Balzarini, Jan
, p. 53 - 76 (2013/04/24)
A series of N2-acyl isonicotinic acid hydrazides (1-17) was synthesized and tested for its in vitro antimycobacterial activity against Mycobacterium tuberculosis and the results indicated that the compound, isonicotinic acid N′- tetradecanoyl-hydrazide (12) was more active than the reference compound isoniazid. The results of antimicrobial activity of the synthesized compounds against S. aureus, B. subtilis, E. coli, C. albicans and A. niger indicated that compounds with dichloro, hydroxyl, tri-iodo and N 2 -tetradecanoyl substituent were the most active ones. The antiviral activity studies depicted that none of the tested compounds were active against DNA or RNA viruses. The multi-target QSAR model was found to be effective in describing the antimicrobial activity of N2-acyl isonicotinic acid hydrazides.
Cucurbituril-resisted acylation of the anti-tuberculosis drug isoniazid via a supramolecular strategy
Cong, Hang,Li, Chun-Rong,Xue, Sai-Feng,Tao, Zhu,Zhu, Qian-Jiang,Wei, Gang
supporting information; scheme or table, p. 1041 - 1046 (2011/04/12)
A chemical investigation reveals that the resistance to acylation of an anti-tuberculosis drug, isoniazid is a consequent result of the inclusion or exclusion of cucurbit[n]urils (n = 6 or 7). The 1H NMR spectra analysis shows that the differen
Synthesis and characterization of 1,3,4-oxadiazole-triazolopyridinone hybrid derivatives as new blue-greenish photoluminescent materials
Chiang, Kuo-Chen,Fung, Fuh Wong,Chang, Chih-Shiang,Hour, Mann-Jen,Wang, Yu-Ling,Wen, Shaw-Bing,Yeh, Mou-Yung
, p. 591 - 596 (2008/09/18)
(Chemical Equation Presented) Recently, New functionalized oxadiazole-triazolopyridinone hybrid compounds were investigated as photoluminescent materials. In this work, we introduce triazolopyridinone to synthesize a series of oxadiazole-triazolopyridinon
An expeditious and convenient one pot synthesis of 2,5-disubstituted-1,3,4-oxadiazoles
Mashraqui, Sabir H.,Ghadigaonkar, Shailesh G.,Kenny, Rajesh S.
, p. 2541 - 2545 (2007/10/03)
A convenient, one pot procedure is reported for the synthesis of a variety of 2,5-disubstituted-1,3,4-oxadiazoles by condensing monoarylhydrazides with acid chlorides in HMPA solvent under the microwave heating. The yields are good to excellent, the process is rapid and does not need any added acid catalyst or dehydrating reagent.
