273-70-1

Basic information

• Product Name: thiazolo[5,4-c]pyridine
• Synonyms: [1,3]Thiazolo[5,4-c]pyridine; Thiazolo[5,4-c]pyridine
• CAS NO: 273-70-1
• Molecular Formula: C₆H₄N₂S
• Molecular Weight: 136.17436
• Mol File: 273-70-1.mol

Chemical Properties

• Melting Point: 105-108 °C(Solv: ethyl ether (60-29-7))
• Boiling Point: 264.282 °C at 760 mmHg
• Flash Point: 119.296 °C
• Appearance: /
• Density: 1.369 g/cm³
• Vapor Pressure: 0.016mmHg at 25°C
• Refractive Index: 1.705
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.33±0.40(Predicted)
• CAS DataBase Reference: thiazolo[5,4-c]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: thiazolo[5,4-c]pyridine(273-70-1)
• EPA Substance Registry System: thiazolo[5,4-c]pyridine(273-70-1)

Safety Data

• Hazardous Substances Data: 273-70-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Thiazolo[5,4-c]pyridine is utilized as a key building block for the synthesis of various pharmaceutical compounds due to its diverse biological activities. Its derivatives have shown potential in the development of anticancer drugs, antifungal agents, and antibacterial medications, making it a crucial component in the creation of novel therapeutics.
Used in Agrochemical Industry:
In the agrochemical sector, Thiazolo[5,4-c]pyridine serves as a vital precursor in the synthesis of compounds with pesticidal properties, contributing to the development of effective solutions for crop protection and management against various pathogens.
Used in Drug Discovery and Development:
Thiazolo[5,4-c]pyridine and its derivatives are employed as valuable tools in drug discovery and development. Their ability to inhibit certain enzymes and receptors makes them promising candidates for the treatment of various diseases, including cancer and infectious diseases.
Used in Medicinal Chemistry and Chemical Biology Research:
The unique structure and wide range of biological activities of Thiazolo[5,4-c]pyridine make it an important subject of study in medicinal chemistry and chemical biology. Researchers use Thiazolo[5,4-c]pyridine to explore its potential applications in the development of new drugs and to understand its interactions with biological systems.

InChI:InChI=1/C6H4N2S/c1-2-7-3-6-5(1)8-4-9-6/h1-4H

Upstream product

• 52334-54-0 4-aminopyridine-3-thiol 
• 64-18-6 formic acid 
• 365996-04-9 4-[(tert-Butoxycarbonyl)amino]-3-mercaptopyridine 
• 98400-69-2 N-(4-pyridyl) t-butyl carbamate 
• 98383-10-9 2-methylthiazolo[5,4-c]pyridine 
• 100724-20-7 (3-mercapto-[4]pyridyl)-carbamic acid benzyl ester 
• 70298-89-4 4-N-pivaloylaminopyridine 
• 129333-20-6 <4-<(2,2-dimethyl-1-oxopropyl)amino>-3-pyridinyl>diethylcarbamodithioate 
• 129333-22-8 <4-(acetylamino)-3-pyridinyl>diethylcarbamodithioate 
• 129333-21-7 <4-amino-3-pyridinyl>diethylcarbamodithioate 

Downstream Products

• 108310-79-8 thiazolo[5,4-c]pyridin-2-ylamine 

Relevant articles and documents

Diamine derivatives

A compound represented by the general formula (1): Q1-Q2-T0-N(R1)-Q3-N(R2)-T1-Q4??(1) wherein R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6-membered cyclic hydrocarbon group which may be substituted, or the like; Q2 is a single bond or the like; Q3 is a group in which Q5 is an alkylene group having 1 to 8 carbon atoms, or the like; and T0 and T1 are carbonyl groups or the like; a salt thereof, a solvate thereof, or an N-oxide thereof. The compound is useful as an agent for preventing and/or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.

NOVEL ETHYLENEDIAMINE DERIVATIVES

A compound represented by the following formula (1):Q-Q-T-N(R)-Q-N(R)-T-Q [wherein, R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6- membered cyclic hydrocarbon group which may have a substituent, or the like; Q2 is a single bond or the like; Q3 represents the following group: -C(R3a)(R4a)-{C(R3b)(R4b)}m1-{C(R3c)(R4c)}m2-{C(R3d)(R4d)}m3-{C(R3e)(R4e)}m4-C(R3f)(R4f)- (in which, R3a to R4e represent hydrogen or the like); T0 represents a carbonyl group or the like; and T1 represents -COCONR- or the like]; or salt thereof, solvate thereof, or N-oxide thereof. The compound is useful as a preventive and/or therapeutic agent for cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.

DIAMINE DERIVATIVES

A compound represented by formula (1):Q1-Q2-To-N(R1) -Q3-N(R2)-T1-Q4 [wherein R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6- membered cyclic hydrocarbon group which may be substituted, or the like; Q2 is a single bond or the like; Q3 represents the following group: (wherein Q5 is an alkylene group having 1 to 8 carbon atoms, or the like); and T0 and T1 are carbonyl groups or the like], a salt thereof, a solvate thereof, or an N-oxide thereof. The compound is useful as an agent for preventing and/or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after artificial valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.

Facile methods for preparation of thiazolopyridine and tetrahydrothiazolopyridine derivatives

The improved routes to prepare tetrahydrothiazolo[5,4-c]-pyridine-2- carboxylic acid lithium salts (2 and 3) were developed. Route A is consisted of the improved preparation of thiazolopyridine intermediates, and Route B is applicable for a large scale synthesis of tetrahydrothiazolo[5,4-c]pyridine-2- carboxylic acid derivatives. The methods we developed may serve as facile means for preparing thiazolopyridine and tetrahydrothiazolopyridine derivatives.

DIAMINE DERIVATIVES

A compound represented by the general formula (1):Q1-Q2-T0-N(R1)-Q3-N(R2)-T1-Q4 wherein R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6- membered cyclic hydrocarbon group which may be substituted, or the like; Q2 is a single bond or the like; Q3 is a group in which Q5 is an alkylene group having 1 to 8 carbon atoms, or the like; and T0 and T1 are carbonyl groups or the like; a salt thereof, a solvate thereof, or an N-oxide thereof. The compound is useful as an agent for preventing and/or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.

ETHYLENEDIAMINE DERIVATIVES

The invention relates a compound represented by the formula (1):Q1-Q2-C(=O)-N(R1)-Q3-N(R2)-T1-Q4 wherein R1 and R2 represent H or the like; Q1 represents an aromatic ring, heterocyclic ring or the like; Q2 represents a single bond, aromatic ring, heterocyclic ring or the like; Q3 represents a group or the like, Q4 represents an aromatic ring, heterocyclic ring or the like; and T1 represents -CO- or -SO2-, and a medicine which comprises the compound and is useful for thrombosis and embolism.