98383-10-9

Basic information

• Product Name: Thiazolo[5,4-c]pyridine, 2-methyl- (6CI,9CI)
• Synonyms: Thiazolo[5,4-c]pyridine, 2-methyl- (6CI,9CI)
• CAS NO: 98383-10-9
• Molecular Formula: C7H6N2S
• Molecular Weight: 150.204
• Product Categories: PYRIDINE
• Mol File: 98383-10-9.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Thiazolo[5,4-c]pyridine, 2-methyl- (6CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Thiazolo[5,4-c]pyridine, 2-methyl- (6CI,9CI)(98383-10-9)
• EPA Substance Registry System: Thiazolo[5,4-c]pyridine, 2-methyl- (6CI,9CI)(98383-10-9)

Safety Data

• Hazardous Substances Data: 98383-10-9(Hazardous Substances Data)

Upstream product

• 19798-77-7 4-amino-3-chloropyridine 
• 926-67-0 O-Ethyl thioacetate 
• 70298-89-4 4-N-pivaloylaminopyridine 
• 129333-20-6 <4-<(2,2-dimethyl-1-oxopropyl)amino>-3-pyridinyl>diethylcarbamodithioate 
• 129333-21-7 <4-amino-3-pyridinyl>diethylcarbamodithioate 
• 64-19-7 acetic acid 
• 116990-43-3 (4-amino-3-pyridyl) N,N-diisopropylcarbamodithioate 
• 116608-24-3 N-(3-Chloro-pyridin-4-yl)-thioacetamide 
• 129333-22-8 <4-(acetylamino)-3-pyridinyl>diethylcarbamodithioate 
• 52334-54-0 4-aminopyridine-3-thiol 
• 108-24-7 acetic anhydride 
• 127-09-3 sodium acetate 
• 100724-20-7 (3-mercapto-[4]pyridyl)-carbamic acid benzyl ester 

Downstream Products

• 273-70-1 thiazolo[5,4-c]-pyridine 
• 52334-54-0 4-aminopyridine-3-thiol 

Relevant articles and documents

Recyclable copper-catalyzed cyclization of o-haloanilides and metal sulfides: An efficient and practical access to substituted benzothiazoles

An efficient heterogeneous copper-catalyzed cyclization of o-haloanilides and metal sulfides has been achieved via the C–S coupling in DMF at 80 or 140 °C in the existence of an MCM-41-bound NHC-Cu(I) catalyst and then intramolecular condensation, delivering a wide range of substituted benzothiazoles in mostly good to high yields. This new MCM-41-NHC-CuI complex can facilely be obtained by a two-step procedure starting from easily accessible and inexpensive reagents and reused more than seven times without any significant loss of its catalytic efficiency. The present protocol has been successfully applied to the gram-scale synthesis of two antitumor agents 5F203 and PMX 610.

A Convenient Procedure for the Formation of 2-Substituted Thiazolopyridines

2-Substituted thiazolo[4,5-b]pyridines and thiazolo[5,4-c]pyridines are prepared in reasonable yields by a procedure involving reaction of a mixture of ortho-amino (diisopropyldithiocarbamato) pyridine, carboxylic acid, and phosphorus oxychloride. The procedure provides a more convenient route than methods involving prior formation and isolation of the acid amide and cyclisation to give the desired product. The procedure is proven to be general for a wide range of substituents.

Nouvelle methode de synthese de thiazolopyridines

It has been established that the direct condensation between aromatic and aliphatic thioesters and the variously generated anion of aminochloropyridines represents the best method for the synthesis of thiazolopyridines.The transient thioamides, sometimes isolated, can be easily converted chemically or photochemically into the desired fused heterocycles.