27318-02-1

Basic information

• Product Name: (S)-α-Bromoisopentanoic acid chloride
• CAS NO: 27318-02-1
• Molecular Weight: 199.475
• Mol File: 27318-02-1.mol
• Article Data: 24

Chemical Properties

• CAS DataBase Reference: (S)-α-Bromoisopentanoic acid chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-α-Bromoisopentanoic acid chloride(27318-02-1)
• EPA Substance Registry System: (S)-α-Bromoisopentanoic acid chloride(27318-02-1)

Safety Data

• Hazardous Substances Data: 27318-02-1(Hazardous Substances Data)

Upstream product

• 108-12-3 isopentanoyl chloride 
• 7726-95-6 bromine 
• 76792-22-8 (R)-2-bromoisovaleric acid 
• 26782-75-2 2S-2-bromo-3-methylbutanoic acid 
• 72-18-4 L-valine 
• 516-06-3 D,L-valine 
• 503-74-2 3-methylbutyric acid 
• 79-37-8 oxalyl dichloride 
• 10323-40-7 2-bromoisovaleric acid 

Downstream Products

• 7472-46-0 2-bromo-3-methylbutyramide 
• 112808-44-3 2-(2-bromo-3-methylbutyryl)amino-4-fluorophenol 
• 112808-46-5 2-bromo-N-(3-chloro-2-hydroxyphenyl)-3-methylbutyramide 
• 112808-55-6 2-(2-bromo-3-methylbutyryl)amino-6-isopropylphenol 
• 112808-53-4 2-(2-bromo-3-methylbutyryl)amino-5-methoxyphenol 
• 112808-71-6 2-bromo-N-(3-tert-butyl-2-hydroxyphenyl)-3-methylbutyramide 
• 112808-67-0 2-(2-bromo-3-methylbutyryl)amino-5-fluorophenol 
• 112808-59-0 2-bromo-N-(3-ethyl-2-hydroxyphenyl)-3-methylbutyramide 
• 112808-48-7 2-(2-bromo-3-methylbutyryl)amino-6-fluorophenol 
• 112808-74-9 8-cyclohexyl-3,4-dihydro-2-isopropyl-2H-1,4-benzoxazin3(4H)-one 
• 143238-76-0 2'-<6'-((2''S-2''-bromo-3''-methylbutanoyl)oxy)>naphthyl 4-decyloxybenzoate 
• 1109268-82-7 (3S,6R)-6-isopropyl-3-methyl-3-phenyl-1,4-dioxane-2,5-dione 

Relevant articles and documents

Benzo six-membered nitrogen heterocyclic compound, preparation method and applications

The present invention provides a benzo six-membered nitrogen heterocyclic compound, a preparation method and applications, wherein the benzo six-membered nitrogen heterocyclic compound has a structurerepresented by a formula I or formula II, and can effectively inhibit the bromine domain receptor and effectively inhibit the proliferation of cancer cells. Compared with the existing reported structure types, the compound of the present invention has different binding mode, has high inhibitory activity, can be used as a drug for treating cancer, cell proliferation disorders, inflammatory diseases, autoimmune diseases, septicemia and viral infections, and has good application prospects and high application value.

A bromine mi suofa synthetic method (by machine translation)

The present invention provides a method for synthesis of bromine mi suofa, belongs to the technical field of drug synthesis, comprising the following steps: S1, in order to α - bromo isovaler ic acid as the raw material, in order to N, N - dimethyl formamide catalytic, adds by drops the chlorination sulfoxide solvent, reaction to obtain the α - bromo different pivaloyl chloride; S2, to S1 obtained in the bromo different α - pivaloyl chloride react with urea, condense and get [...]-cutting crude; S3, refining to obtain [...]-cutting works. The present invention provides a method of synthesis of bromine mi suofa, can effectively avoid the generation of chlorinated by-products, simple process flow, the requirements for apparatus is relatively low, the yield of the product and high purity, and is favorable for industrial production. (by machine translation)

Cobalt-bisoxazoline-catalyzed asymmetric kumada cross-coupling of racemic α-bromo esters with aryl grignard reagents

The first cobalt-catalyzed asymmetric Kumada cross-coupling with high enantioselectivity has been developed. The reaction affords a unique strategy for the enantioselective arylation of α-bromo esters catalyzed by a cobalt-bisoxazoline complex. A variety of chiral α-arylalkanoic esters were prepared in excellent enantioselectivity and yield (up to 97% ee and 96% yield). The arylated products were transformed into α-arylcarboxylic acids and primary alcohols without erosion of ee. The new enantioenriched α-arylpropionic esters synthesized herein are potentially useful in the development of nonsteroidal anti-inflammatory drugs. This method was conducted on gram-scale and applied to the synthesis of highly enantioenriched (S)-fenoprofen and (S)-ar-turmerone.