27339-24-8

Upstream product

• 35573-93-4 3-chloro-1,1-diethoxy-propane 
• 20850-49-1 2-(3,4-dimethoxyphenyl)-3-methylbutyronitrile 
• 93-17-4 3,4-dimethoxyphenylacetonitrile 

Downstream Products

• 27339-25-9 2-(3,4-dimethoxyphenyl)-2-(3-oxopropyl)-2-isopropylacetonitrile 
• 129975-51-5 2-(3,4-Dimethoxy-phenyl)-5-[4-(furan-2-carbonyl)-piperazin-1-yl]-2-isopropyl-pentanenitrile 

Relevant academic research and scientific papers

PROCESS FOR PREPARING N-METHYL-3, 4-DIMETHOXYPHENYLETHYLAMINE

Provided are intermediates useful for the preparation of verapamil and methods for their preparation.

SOME NEW ANALOGUES OF VERAPAMIL AND MEPAMIL. SYNTHESIS AND BASIC PHARMACOLOGICAL PROPERTIES

Some new analogues of verapamil (Ia) and mepamil (Ib), calcium antagonists of arylkylamine type, were synthesized and screened for cardiovascular activities.The basic structure was modified a) on the phenyl ring, attached to the quaternary carbon, b) on the alkyl group, attached to the quaternary carbon and c) on the alkylamino group, attached in position 3 to the n-propyl fragment.Except of 2-(2-chlorophenyl)-2-isopropyl-5-(N-methylhomoveratrylamino)valeronitrile (VIa), all the synthesized compounds exhibited lower hypotensive activity, than the mother compound, verapamil.

Tetrahydroisoquinoline derivatives

Compounds of the formula STR1 wherein R1 and R2 and each independently --H or lower alkoxy; R3 and R4 are each independently lower alkyl; and R5 and R6 are each --OCH3, or together form --OCH2 O-- or --OCH2 CH2 O--, and pharmaceutically acceptable acid addition salts thereof are prepared by cyclizing, deoxygenating, coupling, or hydrogenating the intermediates disclosed herein.