129975-51-5

Basic information

• Product Name: 2-(3,4-Dimethoxy-phenyl)-5-[4-(furan-2-carbonyl)-piperazin-1-yl]-2-isopropyl-pentanenitrile
• Synonyms: 2-(3,4-Dimethoxy-phenyl)-5-[4-(furan-2-carbonyl)-piperazin-1-yl]-2-isopropyl-pentanenitrile
• CAS NO: 129975-51-5
• Molecular Weight: 439.555
• Mol File: 129975-51-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(3,4-Dimethoxy-phenyl)-5-[4-(furan-2-carbonyl)-piperazin-1-yl]-2-isopropyl-pentanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4-Dimethoxy-phenyl)-5-[4-(furan-2-carbonyl)-piperazin-1-yl]-2-isopropyl-pentanenitrile(129975-51-5)
• EPA Substance Registry System: 2-(3,4-Dimethoxy-phenyl)-5-[4-(furan-2-carbonyl)-piperazin-1-yl]-2-isopropyl-pentanenitrile(129975-51-5)

Safety Data

• Hazardous Substances Data: 129975-51-5(Hazardous Substances Data)

Upstream product

• 93-17-4 3,4-dimethoxyphenylacetonitrile 
• 27339-24-8 2-(3,3-diethoxypropyl)-2-(prop-2-yl)-2-(3,4-dimethoxyphenyl)acetonitrile 
• 20850-49-1 2-(3,4-dimethoxyphenyl)-3-methylbutyronitrile 
• 27487-83-8 2-(3,4-dimethoxyphenyl)-2-isopropyl-2-(3-chloropropyl)acetonitrile 
• 40172-95-0 N-(furan-2-carbonyl)piperazine 
• 27339-25-9 2-(3,4-dimethoxyphenyl)-2-(3-oxopropyl)-2-isopropylacetonitrile 

Relevant articles and documents

SOME NEW ANALOGUES OF VERAPAMIL AND MEPAMIL. SYNTHESIS AND BASIC PHARMACOLOGICAL PROPERTIES

Some new analogues of verapamil (Ia) and mepamil (Ib), calcium antagonists of arylkylamine type, were synthesized and screened for cardiovascular activities.The basic structure was modified a) on the phenyl ring, attached to the quaternary carbon, b) on the alkyl group, attached to the quaternary carbon and c) on the alkylamino group, attached in position 3 to the n-propyl fragment.Except of 2-(2-chlorophenyl)-2-isopropyl-5-(N-methylhomoveratrylamino)valeronitrile (VIa), all the synthesized compounds exhibited lower hypotensive activity, than the mother compound, verapamil.