274-26-0

Basic information

• Product Name: 1,3-Benzoxathiole
• Synonyms: 1-Oxa-3-thiaindan; 1,3-Benzoxathiol
• CAS NO: 274-26-0
• Molecular Formula: C₇H₆OS
• Molecular Weight: 138.187
• Mol File: 274-26-0.mol

Chemical Properties

• CAS DataBase Reference: 1,3-Benzoxathiole(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Benzoxathiole(274-26-0)
• EPA Substance Registry System: 1,3-Benzoxathiole(274-26-0)

Safety Data

• Hazardous Substances Data: 274-26-0(Hazardous Substances Data)

Usage

Heterocyclic compound

1,3-Benzoxathiole is a compound that contains a ring of atoms with at least one heteroatom, which is an atom other than carbon.

Benzene ring fused to a thiophene ring

The chemical structure of 1,3-Benzoxathiole consists of a benzene ring fused to a thiophene ring, which is a five-membered ring containing sulfur.

Oxygen atom

The chemical structure of 1,3-Benzoxathiole also includes an oxygen atom.

Potent biological activities

1,3-Benzoxathiole has been found to have potent biological activities, including antitumor, anti-inflammatory, and antimicrobial properties.

Pharmacophore

The chemical structure of 1,3-Benzoxathiole makes it an important pharmacophore, which is a part of a molecule that is responsible for its biological activity.

Medicinal chemistry

1,3-Benzoxathiole is an important compound in the field of medicinal chemistry, which is the study of how drugs work and how they can be used to treat diseases.

Development of new drugs

The unique structure and diverse pharmacological activities of 1,3-Benzoxathiole make it a promising candidate for the development of new drugs.

Treatment of cancer, inflammation, and infectious diseases

1,3-Benzoxathiole has potential therapeutic benefits in the treatment of cancer, inflammation, and infectious diseases.

Further research and studies needed

Further research and studies are needed to fully understand the potential of 1,3-Benzoxathiole in drug discovery and development.

Upstream product

• 1121-24-0 ortho-mercaptophenol 
• 74-97-5 chlorobromomethane 
• 74-95-3 1,1-dibromomethane 

Downstream Products

• 7309-47-9 bis(N-pyrrolidinyl)methane 
• 1121-24-0 ortho-mercaptophenol 
• 1073-29-6 2-(methylsulfenyl)phenol 
• 7217-59-6 2-Methoxybenzenethiol 
• 10333-53-6 bis-(dipropylamino)methane 
• 5419-13-6 N,N'-diethyl-N,N'-diphenyl-methanediyldiamine 
• 102-53-4 bis-(diethylamino)methane 
• 75-11-6 diiodomethane 
• 73726-60-0 2-hydroxythiophenol diacetic ester 
• 6855-71-6 5-Acetyl-1,3-benzoxathiole 
• 1145-27-3 N,N’-dimethyl-N,N’-diphenylmethanediamine 
• 29549-60-8 2-(ethylthio)phenol 

Relevant articles and documents

Bimolecular coupling reactions through oxidatively generated aromatic cations: Scope and stereocontrol

Chromenes, isochromenes, and benzoxathioles react with 2,3-dichloro-5,6- dicyano-1,4-benzoquinone to form stable aromatic cations that react with a range of nucleophiles. These oxidative fragment coupling reactions provide rapid access to structurally div

Synthesis and SAR studies of bicyclic amine series GPR119 agonists

We disclosed a novel series of G-protein coupled receptor 119 (GPR119) agonists based on a bicyclic amine scaffold. Through the optimization of hit compound 1, we discovered that the basic nitrogen atom of bicyclic amine played an important role in GPR119 agonist activity expression and that an indanone in various bicyclic rings was suitable in this series of compounds. The indanone derivative 2 showed the effect of plasma glucose control in oGTT and scGTT in the rodent model.

A re-examination of the methylenation reaction

A re-examination of the methylenation reaction of 1-hydroxy-2-mercapto-, 1,2-dihydroxy- and 1,2-dimercapto-substituted benzenes by bromochloromethane with cesium carbonate shows that these substrates give mixtures of five- and ten-membered benzocondensed heterocyclic compounds and in some cases even dibenzodioxines.

Isoquinolones

Benzo[de]isoquinoline-1,3-dione of Formula or a pharmaceutically acceptable salt thereof wherein R is hydrogen or a protecting group typically used in the art for protecting alcohols and R1-R5are each independently chosen from H, Cl, Br, F, straight or branched alkyl C1-C8alkyl, C3-C8cycloalkyl, heterocycle or bridged heterocycle of 4-9 atoms containing 1-3 heteroatoms, —(CR′2)nOR6, —(CR′2)nN(R6)2, —(CR′2)nNR6COR7, —(CR′2)nNR6SO2OR7, —(CR′2)nNR6SO2N(R6)2, —(CR′2)nOSO2N(R6)2, —(CR′2)nCN, —(CR′2)n(NOR6)R7, NO2, CF3, —(CR′2)nSOmR7, —(CR′2)nSOmR7, —(CR′2)nCO2R6, —(CR′2)nCON(R6)2, Ph, and any two of R1-R5may form a substituted or unsubstituted ring of 5-7 total atoms having 0-2 heteroatoms are claimed which are selective inhibitors of bacterial DNA gyrase and DNA topoisomerase useful in antibacterial agents. Methods for their preparation and formulation as well as novel intermediates useful in the preparation of the final products are also claimed.