7309-47-9

Basic information

• Product Name: 1-(pyrrolidin-1-ylmethyl)pyrrolidine
• Synonyms: 1-(pyrrolidin-1-ylmethyl)pyrrolidine;1,1'-Methylenebispyrrolidine;1,1'-Methylenedipyrrolidine;Dipyrrolizinomethane
• CAS NO: 7309-47-9
• Molecular Formula: C₉H₁₈N₂
• Molecular Weight: 154.25
• Mol File: 7309-47-9.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(pyrrolidin-1-ylmethyl)pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(pyrrolidin-1-ylmethyl)pyrrolidine(7309-47-9)
• EPA Substance Registry System: 1-(pyrrolidin-1-ylmethyl)pyrrolidine(7309-47-9)

Safety Data

• Hazardous Substances Data: 7309-47-9(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 91, p. 5663, 1969 DOI: 10.1021/ja01048a053

Upstream product

• 123-75-1 pyrrolidine 
• 50-00-0 formaldehyd 
• 274-26-0 1,3-benzoxathiole 
• 75-09-2 dichloromethane 
• 61324-75-2 1,1'-methylenebis-2-pyrrolidinone 
• 156101-33-6 (chloromethyl)trimethoxygermane 
• 16473-66-8 L-(+)-1,1'-methylenebis[5-oxo-2-pyrrolidinecarboxylic acid] 
• 77269-12-6 hydrazide de l'acide L methylene bis N-(oxo-5 pyrrolidine carboxylique-2) 
• 77269-17-1 dichlorhydrate de la L methylene bis N-(amino-5 pyrrolidinone-2) 
• 77269-14-8 diazide de l'acide L methylene bis N-(oxo-5 pyrrolidine carboxylique-2) 
• 77269-11-5 L methylene bis N-(oxo-5 pyrrolidine carboxylate-2 de methyle) 
• 77269-15-9 L methylene bis N-(oxo-5 pyrrolidine-2 isocyanate) 
• 56747-10-5 chlorure de l'acide L methylene bis N-(oxo-5 pyrrolidine carboxylique-2) 
• 343778-28-9 methylene bis N-(hydroxy-5 pyrrolidinone-2) 

Downstream Products

• 233279-11-3 (E)-2-(Hydroxyimino)-3-(1-pyrrolidinyl)-N-phenylpropanamid 
• 4096-21-3 N-phenylpyrrolidine 
• 58325-60-3 1-[(2E)-3-phenylprop-2-en-1-yl]pyrrolidine 
• 1370700-68-7 4-{5,7-dihydroxy-4-oxo-6,8-bis[(pyrrolidin-1-yl)methyl]-4H-chromen-3-yl}phenyl-β-D-glucopyranoside 

Relevant articles and documents

The Reaction of Amines with Methylene Chloride. Evidence for Rapid Aminal Formation from N-Methylenepyrrolidinium Chloride and Pyrrolidine

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Method for preparing kakonein derivatives

The invention discloses a puerarin derivative preparation method. Puerarin derivative has the structural formula as shown in the specification, and the puerarin derivative is obtained by that puerarin reacts with CH2(R)2, wherein R is a tertiary amine gene. The puerarin derivative preparation method is characterized in that reaction is carried out under hydrochloric acid catalysis. Compared with the prior art, the puerarin derivative preparation method is characterized in that the yield of a puerarin derivative product can be obviously improved after the class of reaction adopts hydrochloric acid catalysis.

Substituted Sulfonamide Compounds

Substituted sulfonamide compounds corresponding to the formula I wherein m, n, p, Q, R1, R2, R3, R4, X, Y and Z have the respective meanings defined herein, pharmaceutical compositions containing such compounds, a process for their preparation, and the use of such compounds for the treatment and/or inhibition of pain and other conditions mediated by bradykinin receptor 1 (B1R) and/or bradykinin receptor 2 (B2R).

Synthesis, characterization, and anti-amoebic screening of core-modified 5,20-bis{2-{[(alkyl)(alkyl′)amino]methyl}ferrocen-1-yl}-10,15-diphenyl-21, 23-dithiaporphyrin (=1,1″-(10,15-diphenyl-21,23-dithiaporphine-5,20-diyl) bis[2-{[(alkyl)(alkyl′)amino]methyl}ferrocene]) derivatives

The synthesis of the first bis-ferrocenyl-substituted core-modified porphyrins, 5,20-bis{2-{[(alkyl)-(alkyl′)amino]methyl}ferrocen-1-yl}-10, 15-diphenyl-21,23-dithiaporphyrin derivatives 6a - 6j, via a multistep route is reported (Schemes 1, 2, and 4). The synthesis was carried out through acid-catalyzed (BF3 ? Et2O) condensation of 1,1″- [thiophene-2,5-diylbis(hydroxymethyl)]bis[2-{[(alkyl)(alkyl′)amino]methyl} ferrocenes] 4a - 4j with 2,2′-[thiophene-2,5-diylbis(phenylmethylene)] bis[1H-pyrrole] (5b) in presence of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (=4,5-dichloro-3,6-dioxocyclohexa-1,4-diene-1,2-dicarbonitrile; DDQ). Characterization of the compounds was done at each step by means of various spectroscopic techniques. The final compounds were screened for in vitro anti-amoebic activity against the strain HM1:IMSS of E. histolytica (Table 2).