276251-83-3

Basic information

• Product Name: 2-BroMo-4,6-diMethoxy-pyridine
• Synonyms: 2-BroMo-4,6-diMethoxy-pyridine
• CAS NO: 276251-83-3
• Molecular Formula: C₇H₈BrNO₂
• Molecular Weight: 218.04792
• Mol File: 276251-83-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-BroMo-4,6-diMethoxy-pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BroMo-4,6-diMethoxy-pyridine(276251-83-3)
• EPA Substance Registry System: 2-BroMo-4,6-diMethoxy-pyridine(276251-83-3)

Safety Data

• Hazardous Substances Data: 276251-83-3(Hazardous Substances Data)

Usage

General Description

2-Bromo-4,6-dimethoxy-pyridine is a chemical compound with the molecular formula C7H8BrNO2. It is a pyridine derivative with two methoxy groups and a bromine atom attached to the 2 and 6 positions of the pyridine ring, respectively. 2-BroMo-4,6-diMethoxy-pyridine is widely used in organic synthesis as a versatile building block for the preparation of various pharmaceuticals, agrochemicals, and functional materials. Additionally, it is utilized as a reagent in the synthesis of heterocyclic compounds and as a precursor in the production of other organic compounds. Due to its reactive nature and useful synthetic applications, 2-bromo-4,6-dimethoxy-pyridine is an important compound in the field of organic chemistry.

Upstream product

• 2408-70-0 2,4,6-tribromopyridine 
• 124-41-4 sodium methylate 
• 175422-04-5 2,6-dibromo-4-nitropyridine 
• 98027-81-7 2,6-dibromo-4-nitro-pyridine 1-oxide 
• 25373-69-7 2,6-dibromopyridin N-oxide 
• 626-05-1 2,6-Dibromopyridine 

Downstream Products

• 18677-43-5 2,4-dimethoxypyridine 

Relevant articles and documents

Inhibition of cancer-associated mutant isocitrate dehydrogenases: Synthesis, structure-activity relationship, and selective antitumor activity

Mutations of isocitrate dehydrogenase 1 (IDH1) are frequently found in certain cancers such as glioma. Different from the wild-type (WT) IDH1, the mutant enzymes catalyze the reduction of α-ketoglutaric acid to d-2-hydroxyglutaric acid (D2HG), leading to cancer initiation. Several 1-hydroxypyridin-2-one compounds were identified to be inhibitors of IDH1(R132H). A total of 61 derivatives were synthesized, and their structure-activity relationships were investigated. Potent IDH1(R132H) inhibitors were identified with Ki values as low as 140 nM, while they possess weak or no activity against WT IDH1. Activities of selected compounds against IDH1(R132C) were found to be correlated with their inhibitory activities against IDH1(R132H), as well as cellular production of D2HG, with R2 of 0.83 and 0.73, respectively. Several inhibitors were found to be permeable through the blood-brain barrier in a cell-based model assay and exhibit potent and selective activity (EC50 = 0.26-1.8 μM) against glioma cells with the IDH1 R132H mutation.