2774-84-7Relevant articles and documents
Lindhoudt,J.C. et al.
, p. 2565 - 2568 (1976)
Stereoselective synthesis of C3–C17 and C18–C34 subunits of bullatanocin utilizing α-chloro sulfide intermediates
Chowhan, L. Raju,Raghavan, Sadagopan
, (2019)
A convergent synthesis of bullatanocin is envisaged by the union of C18–C34, C3–C17 and the butenolide subunits. The synthesis of the C3–C17 and C18–C34 subunits is disclosed that takes advantage of the chirality of tartaric acid for 1,2-asymmetric induct
Stereoselective Synthesis of Perfluoroalkylated (E,E)-Dienes from Perfluoroalkylated Alkynes. The Synthesis of Fluorinated Analogs of Lepidoptera Pheromones
Wang, Zhong,Lu, Xiyan
, p. 11765 - 11774 (1995)
Pd(dba)2 -HOAc catalyzed the isomerization of 1-perfluoroalkyl-1-alkynes to give 1-perfluoroalkyl-(1E,3E)-dienes in good yield and stereoselectivity; the fluorinated analogs of Lepidoptera species sex pheromone attractants were synthesized applying this method.
IMMUNOTHERAPEUTIC AGENT
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Paragraph 0101-0102, (2018/07/29)
Compounds for use in the treatment of sepsis and/or the prevention or treatment of post-sepsis syndrome.
Enantioselective Rhodium-Catalyzed Atom-Economical Macrolactonization
Ganss, Stephanie,Breit, Bernhard
supporting information, p. 9738 - 9742 (2016/08/10)
A highly attractive route toward macrolactones, which form the cyclic scaffold of a multitude of diverse natural compounds, is described. Although many chemical approaches to this structural motif have been explored, an asymmetric variant of the cyclization is unprecedented. Herein we present an enantioselective macrolactonization through an intramolecular atom-economical rhodium-catalyzed coupling of ω-allenyl-substituted carboxylic acids. The use of a modified diop ligand, chiral DTBM-diop, led to high enantioselectivity (up to 93 % ee). The reaction tolerated a large variety of functionalities, including α,β-unsaturated carboxylic acids and depsipeptides, and provided the desired macrocycles with very high enantio- and diastereoselectivity.
