27798-44-3

Usage

Chemical family

Acetophenone

Bromine atom position

Attached to the third carbon of a phenyl ring

Ketone group position

On the second carbon of the phenyl ring

Common uses

Production of pharmaceuticals, perfumes, and flavorings; intermediate in the synthesis of other organic compounds

Research and industrial applications

Unique structure makes it valuable

Health hazards

May pose health hazards if not handled properly

InChI:InChI=1/C14H11BrO/c15-13-8-4-5-11(9-13)10-14(16)12-6-2-1-3-7-12/h1-9H,10H2

Upstream product

• 880647-91-6 2-(3-bromo-benzylsulfanyl)-2'-iodo-biphenyl 
• 98-88-4 benzoyl chloride 
• 1878-67-7 3-Bromophenylacetic acid 
• 71-43-2 benzene 
• 16717-64-9 1-azidostyrene 
• 40887-80-7 3-bromophenylhydrazine 
• 591-17-3 meta-bromotoluene 
• 611-73-4 Benzoylformic acid 
• 100-42-5 styrene 
• 823-78-9 meta-bromobenzyl bromide 
• 880647-84-7 benzenethiosulfonic acid S-(3-bromobenzyl) ester 
• 98288-51-8 2-(3-bromophenyl)acetyl chloride 

Downstream Products

• 660832-20-2 3-(3-bromo-phenyl)-2-phenyl-1H-indole 
• 660832-22-4 3'-(2-oxo-2-phenyl-ethyl)-biphenyl-4-carboxylic acid ethyl ester 
• 660832-18-8 3'-(2-phenyl-1H-indol-3-yl)-biphenyl-4-carboxylic acid ethyl ester 
• 660832-23-5 3'-(2-phenyl-1H-indol-3-yl)-biphenyl-3-carboxylic acid ethyl ester 
• 40396-54-1 1-(3-bromophenyl)-2-phenylethane-1,2-dione 
• 1443223-47-9 C₂₂H₁₉BrO 

Relevant academic research and scientific papers

H2O2-mediated room temperature synthesis of 2-arylacetophenones from arylhydrazines and vinyl azides in water

An environmentally benign, cost-efficient and practical methodology for the room temperature synthesis of 2-arylacetophenones in water has been discovered. The facile and efficient transformation involves the oxidative radical addition of arylhydrazines with α-aryl vinyl azides in the presence of H2O2 (as a radical initiator) and PEG-800 (as a phase-transfer catalyst). From the viewpoint of green chemistry and organic synthesis, the present protocol is of great significance because of using cheap, non-toxic and readily available starting materials and reagents as well as amenability to gram-scale synthesis, which provides an attractive strategy to access 2-arylacetophenones.

Ruthenium(II)-Catalyzed Cross-Coupling of Benzoyl Formic Acids with Toluenes: Synthesis of 2-Phenylacetophenones

Herein, we report a direct method to synthesize 2-phenylacetophenone through a ruthenium(II)-catalyzed cross-coupling reaction between acyl and benzyl radical. The various derivatives of 2-phenylacetophenone were prepared easily in moderate to good yields. These reactions provide a straightforward pathway to synthesize a variety of ketones bearing various functional groups.

Tailoring the Molecular Properties with Isomerism Effect of AIEgens

It is challenging to achieve precise control on the properties of organic π-functional materials to widen their practical applications. On the other hand, the study of aggregation-induced emission luminogens (AIEgens) helps achieve such goals because of i

Copper-catalyzed base-accelerated direct oxidation of C-H bond to synthesize benzils, isatins, and quinoxalines with molecular oxygen as terminal oxidant

We describe herein an efficient and general copper (II)-catalyzed base-accelerated oxidation of the C-H bond to synthesize benzils and isatins. With similar oxidation system an efficient one-pot procedure for the synthesis of quinoxaline derivatives was realized. The two protocols feature using molecular oxygen as terminal oxidant, low catalyst loading, wide substrate scope, and high functional-group tolerance.

Catalyst-controlled highly selective coupling and oxygenation of olefins: A direct approach to alcohols, ketones, and diketones

Oxygen? That's radical! A method for the direct synthesis of substituted alcohols, ketones, and diketones through a catalyst-controlled highly chemoselective coupling and oxygenation of olefins has been developed. The method is simple and practical, can be switched by the selection of different catalysts, and employs molecular oxygen as both an oxidant and a reagent. Copyright

Functionalized benzylic magnesium reagents through a sulfur-magnesium exchange

(Chemical Equation Presented) Switch it: lodobiphenyl thioethers readily undergo an iodine-magnesium exchange followed by, after the addition of tBuOLi, an intramolecular sulfur-magnesium exchange, which provides benzylic magnesium reagents in excellent yield through a fragmentation reaction.

Structure-based design of carboxybiphenylindole inhibitors of the ZipA-FtsZ interaction.

Structural features of two weak inhibitors of the ZipA-FtsZ protein-protein interaction which were found to bind to overlapping but different areas of the key binding site were combined in one new series of carboxybiphenyl-indoles with improved inhibitory