27822-59-9Relevant articles and documents
Determination of the synthetic origin of methamphetamine samples by 2H NMR spectroscopy
Armellin, Silvia,Brenna, Elisabetta,Frigoli, Samuele,Fronza, Giovanni,Fuganti, Claudio,Mussida, Daniele
, p. 3113 - 3117 (2008/02/09)
Samples of methamphetamine, prepared according to the most common synthetic pathways, were submitted to natural-abundance 2H NMR spectroscopy. The deuterium content at the various sites of the molecule was found to depend on its synthetic history. The technique provides a chemical fingerprint of methamphetamine samples and can give hints to trace back the starting materials and the synthetic procedures.
Asymmetric organic synthesis. Preparation and Birch reduction-alkylation of 2-methyl-3,4-dihydroisoquinolin-1-ones
Schultz, Arthur G.,Kirincich, Steven J.,Rahm, Rainer
, p. 4551 - 4554 (2007/10/02)
Birch reductions of 2-methyl-3,4-dihydroisoquinolin-1-ones 1 and 6 generate enolates 2a and 2b and alkylations provide 1,4-cyclohexadienes 3a-3e and 7a-7c. The synthesis of a racemic structural analogue, 9, of the potent analgetic levorphanol is described.
1-Ethoxy-3,4-dihydroisoquindines
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, (2008/06/13)
1-(2-Substituted-hydrazino)-3,4-dihydroisoquinolines, prepared in one process by alkylating the corresponding 3,4-dihydroisocarbostyrils, hydrazinolyzing the resulting 1-alkoxy-3,4-dihydroisoquinolines and condensing the resulting 1-hydrazIno-3,4-dihydroisoquinolines with aldehydes or ketones, and 1,1'-azinobis(1,2,3,4-tetrahydroisoquinolines), prepared by condensing corresponding 1-alkoxy-3,4-dihydroisoquinolines and 1-hydrazino-3,4-dihydroisoquinolines, are useful as antihypertensive agents and/or as antiinflammatory agents.