2817-71-2

Usage

Synthesis Reference(s)

Synthetic Communications, 20, p. 2849, 1990 DOI: 10.1080/00397919008051498

InChI:InChI=1/C5H8N2/c1-2-7-5-3-4-6-7/h3-5H,2H2,1H3

Upstream product

• 288-13-1 NH-pyrazole 
• 74-96-4 ethyl bromide 
• 75-03-6 ethyl iodide 
• 540-51-2 2-bromoethanol 

Downstream Products

• 87581-72-4 (p-methylphenyl)-bis(1-ethylpyrazol-5'-yl)carbinol 
• 288-13-1 NH-pyrazole 
• 74-85-1 ethene 
• 71229-85-1 4-bromo-1-ethyl-1H-pyrazole 
• 902837-62-1 1-ethyl-1H-pyrazole-5-carbaldehyde 
• 943106-34-1 C₈H₁₅N₃ 
• 933778-29-1 N-ethyl-1H-5-methylpyrazole-4-carboxaldehyde 
• 1047645-57-7 4-(4-bromo-1-ethyl-1H-pyrazol-5-yl)-N-((1S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-2-thiophenecarboxamide 
• 1047645-54-4 4-(4-chloro-1-ethyl-1H-pyrazol-5-yl)-N-((1S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-2-thiophenecarboxamide 
• 1047644-59-6 N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-4-(4-bromo-1-ethyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide 
• 1047644-58-5 N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-4-(4-chloro-1-ethyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide 
• 1047645-47-5 1,1-dimethylethyl [2-({[5-chloro-4-(1-ethyl-1H-pyrazol-5-yl)-2-thienyl]carbonyl}amino)-3-phenylpropyl]carbamate 
• 1047644-54-1 N-[2-amino-1-(phenylmethyl)ethyl]-5-chloro-4-(1-ethyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide 
• 1007110-53-3 1-ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 

Relevant academic research and scientific papers

Enthalpies of combustion, heat capacities, and enthalpies of vaporization of 1-ethylimidazole and 1-ethylpyrazole

The standard (p° = 0.1 MPa) molar enthalpies of formation for liquid 1-ethylimidazole and 1-ethylpyrazole were derived from the standard molar enthalpies of combustion ΔcH°m, in oxygen, at T = 298.15 K, measured by static bomb combustion calorimetry. The molar heat capacities of both liquids were measured in the temperature range (280 to 365 ) K by differential scanning calorimetry. The standard molar enthalpies of vaporization Δg1H°m, at the temperature T = 298.15 K were measured by Calvet microcalorimetry. The derived standard molar enthalpies of formation in the gaseous state are compared. -ΔcH°m(1)/(kJ·mol-1) Δg1H°m/(kJ·mol-1) 1-Ethylimidazole 3155.7 + 4.7 66.0 + 3.9 1-Ethylpyrazole 3190.2 + 2.1 53.3 + 2.4

Benzyl pyrazole ionic liquid compound as well as preparation method and application thereof

The invention discloses a benzyl pyrazole ionic liquid compound which is a macromolecule with the relative molecular mass ranging from 200 to 500 and can cover more metal surfaces. The adsorption capacity of the compound and metal and metal alloy surfaces is improved. The compound contains N, F, O, P, B and S heteroatoms, and the heteroatoms contain lone pair electrons, so that the compound is easy to interact with metal, and a barrier is formed between the surfaces of the metal and the alloy thereof and a corrosive medium, thereby reducing the corrosion speed of the metal and the alloy thereof. The invention further discloses a preparation method of the benzyl pyrazole ionic liquid compound. The method is simple in synthesis process and mild in reaction condition. The invention also discloses an application of the benzyl pyrazole ionic liquid as a corrosion inhibitor for metals and alloys thereof. The benzyl pyrazole ionic liquid has a very good application prospect in the aspect of retarding corrosion of metals and alloys thereof in an environmental medium.

Protonated alkylpyrazole ionic liquid and method using same for synthesizing cyclic carbonate

The invention relates to protonated alkylpyrazole ionic liquid with a structural formula as shown in the description, wherein n is equal to 1, 2, 3 or 4, and X is Cl, Br or I. The invention further discloses a method for synthesizing cyclic carbonate by using the protonated alkylpyrazole ionic liquid; the protonated alkylpyrazole ionic liquid and an epoxy compound are added into a high-pressure reaction kettle according to a molar ratio of 1 : (25 to 300), CO2 is introduced until pressure is 1-3 MPa, and constant-temperature constant-pressure reaction is performed for 1-5 hours at a temperature of 100-150 DEG C, and post-treatment is performed after reaction is ended, thus obtaining the cyclic carbonate. The method solves the problems that CO2 activation is difficulty, a catalyst is dear, a poisonous organic solvent is used, a synthesis process is complex, reaction conditions are harsh and the like in an existing method. The advantages of simple synthesis process, high catalyst activity, environmental friendliness, low cost and the like are achieved.

Pyrazolium-based electrolyte for solid-state dye-sensitized solar cells with high fill factor and open-circuit voltage

Further development of solid-state dye-sensitized solar cells (ssDSSCs) requires good fill factor as well as high photon to electron conversion efficiency. We synthesized a pyrazolium-based dication organic ionic conductor with good thermal stability and high ionic diffusion coefficient, Py2C6. This pyrazolium-based electrolyte for ssDSSC achieves an efficiency of 7.30% with a fill factor of up to 79.6% and an open-circuit voltage of 779 mV, which are superior to the respective parameters reported in the previous literature. The obtained cell was characterized by electrochemical impedance spectra (EIS), cyclic voltammetry (CV) and Tafel plot. The results show 24.43 Ω series resistance and 3.31 kΩ shunt resistance, very close to the values for the device with a frequently used liquid-state electrolyte, and these are the major contributors to the high fill factor. The back reaction of photoelectrons at the TiO2/electrolyte interface can also be markedly restrained as a result of the large recombination resistance, thus prolonging the electron lifetime. These factors, together with the remarkable catalytic activity of the counter electrode, lead to good photovoltaic parameters of the cell containing Py2C6. In stability tests, this device shows excellent long-term stability, maintaining 92% of the initial efficiency after 1000 h.

NEW THIENOPYRIMIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R12, X, A and n are as defined in the description.

SMALL MOLECULE INHIBITORS OF IL-6 AND USES THEREOF

In one aspect, the invention relates to substituted 2-(lH-indol-3-yl)ethanol analogs and substituted 3,3a,8,8a-tetrahydro-2H-furo[2,3-b]indole analogs, derivatives thereof, and related compounds, which are useful as inhibitors of IL-6 mediated activation of the Jak2/STAT3 pathway; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation associated with a IL6 dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Synthesis of 1-ethylpyrazole-4-carbaldehydes, 1,1′-methylenebis(3,5- dimethylpyrazole-4-carbaldehyde), and Schiff bases derived therefrom

New pyrazole-containing aldehydes, 1-ethylpyrazole-4-carbaldehyde, 1-ethyl-3,5-dimethylpyrazole-4-carbaldehyde, and 1,1′-methylenebis(3,5- dimethylpyrazole-4-carbaldehyde), were synthesized by the Vilsmeier reaction. Their reactions with primary amines (a

Synthesis of N-Alkylpyrazoles by Phase Transfer Catalysis without Solvent

The alkylation of pyrazole is performed by phase transfer catalysis without solvent.High yields of N-alkylpyrazoles are obtained and the principal problems in the alkylation are suitably solved.

Influence of N-substitution in the FVT of pyrazoles

Flash vacuum thermolysis of 1-ethyl (3), 3,5-dimethyl-1-ethyl (4), 1-n-buthyl (5), 1-tert-butyl (6), 3,5-dimethyl-1-phenyl (7) and 1-phenyl-pyrazole (8) was studied.In the N-alkyl derivatives, pyrazole elimination and olefin formation was found.In contrast, phenylderivatives afforded isomerization and nitrogen extrusion.Kinetic parameters for compound 4 are described and a general mechanism including the N-H derivatives is discussed.