2819-56-9

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 70, p. 3021, 1948 DOI: 10.1021/ja01189a055

InChI:InChI=1/C10H14O4/c11-8-6-7(9(12)13)10(14-8)4-2-1-3-5-10/h7H,1-6H2,(H,12,13)

Upstream product

• 108-30-5 succinic acid anhydride 
• 108-94-1 cyclohexanone 
• 134515-27-8 2-oxo-1-oxaspiro<4,5>decan-3,4-dicarboxylic acid diethyl ester 
• 7647-01-0 hydrogenchloride 
• 82546-67-6 cyclohex-1-enyl-succinic acid-1-ethyl ester 
• 110-17-8 (2E)-but-2-enedioic acid 
• 108-93-0 cyclohexanol 
• 61858-03-5 ethyl 2-oxo-1-oxaspiro<4,5>decane-4-carboxylate 
• 141-05-9 Diethyl maleate 

Downstream Products

• 137180-64-4 2-oxo-4-chloroacetyl-1-oxaspiro<4,5>decane 
• 31537-06-1 2-oxo-1-oxa-spiro[4.5]decane-4-carboxylic acid anilide 
• 136547-37-0 2-Oxo-1-oxa-spiro[4.5]decane-4-carboxylic acid amide 
• 136547-39-2 2-Oxo-1-oxa-spiro[4.5]decane-4-carboxylic acid dimethylamide 
• 136547-40-5 2-Oxo-1-oxa-spiro[4.5]decane-4-carboxylic acid diethylamide 
• 136547-41-6 4-(Morpholine-4-carbonyl)-1-oxa-spiro[4.5]decan-2-one 
• 136547-38-1 2-Oxo-1-oxa-spiro[4.5]decane-4-carboxylic acid benzylamide 

Relevant academic research and scientific papers

Continuous-Flow Preparation of γ-Butyrolactone Scaffolds from Renewable Fumaric and Itaconic Acids under Photosensitized Conditions

The method and results described herein concern the photosensitized addition of various alcohols to renewable platform fumaric and itaconic acids under scalable continuous-flow conditions in glass micro- and mesofluidic reactors. Alcohols were used both as reagents and as solvents, thus contributing to a reduced environmental footprint. Process parameters such as the temperature, light intensity, and the nature as well as amount of the photosensitizer were assessed under microfluidic conditions and, next, transposed to a lab-scale mesofluidic reactor connected with an in-line NMR spectrometer for real-time reaction monitoring. Substituted γ-butyrolactones, including spiro derivatives with unique structural features, were obtained with quantitative conversion of the starting materials and in 47-76% isolated yields. The model photoaddition of isopropanol to fumaric acid was next successfully transposed in a pilot-scale continuous-flow photoreactor to further demonstrate scalability.

Preparation and applications for spiro-amide compounds

The invention belongs to the field of an agricultural fungicide, an agricultural insecticide and an agricultural acaricide and specifically discloses two spiro-amide compounds and applications for thespiro-amide compounds as pesticides. The spiro-amide compounds are shown in the general formula (I) and the general formula (II), the biological activity determination shows that the compound has broad spectrum bactericidal activity, the compound has good effects on the disease of a plurality of crops (paddy rice, wheat, corn, bean, vegetable, fruit), and especially the compound has excellent activity for powdery mildew. The compound has good insecticidal activity at the same time, and especially has special effects on Panonychus citri. The compound is suitable for the integration preventionof the disease and insect pest on various crops. The threaded ring amide compounds are shown in the description.

COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A POLYMER BEARING JUNCTION GROUPS, AND COSMETIC TREATMENT PROCESS

The present patent application relates to a cosmetic or dermatological composition comprising, in a cosmetically or dermatologically acceptable medium, a polymer comprising: (a) a polymer backbone that may be obtained by reaction: of a polyol comprising 3 to 6 hydroxyl groups;of a monocarboxylic acid containing 6 to 32 carbon atoms;of a polycarboxylic acid comprising at least two carboxylic groups COOH, and/or of a cyclic anhydride such as a polycarboxylic acid and/or of a lactone comprising at least one carboxylic group COOH; and(b) at least one junction group linked to the said polymer backbone and capable of establishing H bonds with one or more partner junction groups, each pairing of a junction group involving at least three H (hydrogen) bonds. The patent application also concerns a cosmetic treatment process using the said composition.

SYNTHESIS OF NEW DERIVATIVES OF CARBO(HETERO)CYCLOSPIROBUTANOIC LACTONES

The diethyl esters of 2-oxo-1-oxaspirononan-3,4-dicarboxylic, 2-oxo-1-oxaspirodecan-3,4-dicarboxylic and 7,7-di-methyl-1,8-dioxaspiro-decan-3,4-dicarboxylic acids (Ia-c) are transformed by hydrochloric acid into 2-oxo-1-oxa-spirononan-

Mechanism of formation of 5,5-cyclopentamethylene-3,4-dicarbethoxyfuranone-2 from ethyl β,β-pentamethyleneglycidate and diethyl malonate

An O18 isotope study of the reaction of glycidate (1c) with diethyl malonate leading to a furanone diester (2d) reveal that there is a ring cleavage followed by an intramolecular cyclisation.Isotopic evidence for the Darzen's reaction is given.The glycidate (1c) does not undergo cleavage with benzylamine, however with hydrogen chloride a chlorohydrin through the cleavage of the epoxide ring is obtained.

A CONVENIENT SYNTHESIS OF 4-SUBSTITUTED PARACONIC ACIDS

A mixture of zinc chloride and triethylamine effects the condensation of aryl aldehydes and of ketones with succinic anhydride to give paraconic acids.