2850-26-2

Basic information

• Product Name: ethyl n‐[(4‐methylbenzenesulfonyl)methyl]carbamate
• Synonyms: ethyl n‐[(4‐methylbenzenesulfonyl)methyl]carbamate;Ethyl (tosylmethyl)carbamate;Ethyl N-(p-tolylsulfonylmethyl)carbamate
• CAS NO: 2850-26-2
• Molecular Formula: C₁₁H₁₅NO₄S
• Molecular Weight: 257.3061
• Mol File: 2850-26-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl n‐[(4‐methylbenzenesulfonyl)methyl]carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl n‐[(4‐methylbenzenesulfonyl)methyl]carbamate(2850-26-2)
• EPA Substance Registry System: ethyl n‐[(4‐methylbenzenesulfonyl)methyl]carbamate(2850-26-2)

Safety Data

• Hazardous Substances Data: 2850-26-2(Hazardous Substances Data)

Usage

General Description

Ethyl n‐[(4‐methylbenzenesulfonyl)methyl]carbamate, also known as sulindac, is a nonsteroidal anti-inflammatory drug (NSAID) that is used to reduce pain, inflammation, and swelling. It works by inhibiting the production of prostaglandins, which are chemicals in the body that cause inflammation and pain. Sulindac is commonly prescribed for the treatment of conditions such as arthritis, gout, and ankylosing spondylitis. It is available in oral tablet form and is usually taken with food to minimize stomach irritation. Like other NSAIDs, it can have side effects such as stomach upset, heartburn, and dizziness, and it may also increase the risk of serious cardiovascular events. Therefore, it should be used with caution and under the supervision of a healthcare professional.

Upstream product

• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 64-17-5 ethanol 
• 10564-55-3 1-isocyanatomethanesulfonyl-4-methyl-benzene 
• 14738-27-3 ethyl (p-tolylthio)acetate 
• 28126-38-7 N--thiocarbaminsaeure-O-ethylester 
• 2850-19-3 (toluene-4-sulfonyl)-acetic acid ethyl ester 
• 50-00-0 formaldehyd 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 51-79-6 urethane 
• 30014-36-9 N-(Tosylmethyl)-carbamoylchlorid 
• 2850-22-8 p-toluenesulfonylacethydrazide 

Downstream Products

• 2881-09-6 p-Toluolsulfonylformaldehyd-(triphenylphosphoranyliden-hydrazon) 
• 7569-26-8 chloromethyl p-tolylsulfone 
• 1538-98-3 p-tosyldiazomethane 
• 15645-75-7 1,1’-[(Z)-ethene-1,2-diyldisulfonyl]bis(4-methylbenzene) 
• 15717-50-7 E-ditosylethene 
• 875011-80-6 (+)-2-n-amyl-2-cyclopropenyl-4-tolyl sulfone 
• 875011-86-2 (-)-cis-1-methyl-4-(2-pentyl-cyclopropanesulfonyl)-benzene 
• 875011-96-4 (+/-)-2-n-amyl-2-cyclopropenyl-4-tolyl sulfone 

Relevant articles and documents

Synthesis method of sulfonyl carbamate

The invention discloses a synthesis method of sulfuryl carbamate, and the method comprises the following steps: by taking sodium aromatic sulfinate, ethyl carbamate and paraformaldehyde as reaction raw materials, carrying out catalytic reaction under the action of a reaction catalyst and under the conditions of heating and pressurizing to prepare the sulfuryl carbamate. The synthesis method is easy and convenient to operate and low in production cost, the adopted synthesis raw materials are low in price, easy to obtain, non-toxic, green and environmentally friendly, the obtained target product is high in purity and ideal in yield, and large-scale production of the sulfuryl carbamate can be achieved.

Mild oxidation of tosylmethylisocyanide to tosylmethylisocyanate: Utility in synthetic and medicinal chemistry

A convenient and efficient (one-step) oxidation is reported of commercially available tosylmethylisocyanide (TOSMIC) to form tosylmethylisocyanate, making this highly reactive bifunctional molecule a readily available synthetic reagent. Besides engaging in nucleophilic addition reactions with alcohols, amines, and thiols, tosylmethylisocyanate also reacts with carboxylic acids to form tosylmethylamides, which undergo substitution reactions in the presence of organocopper and organomagnesium reagents.

Improved preparation of tosyldiazomethane

Treatment of the carbamate 2a by i-amyl nitrite and TMSCl in presence of a reduced amount of pyridine, followed by decomposition of the resulting nitroso derivative 3a with activated alumina afforded in high yield the pure, crystalline, diazosulfone 1a, a