285995-01-9

Upstream product

• 226398-62-5 4-(4-bromobenzenesulfonyl)piperidine-1-carboxylic acid tert-butyl ester 
• 188527-03-9 4-(4-bromophenylsulfanyl)piperidine-1-carboxylic acid tert-butyl ester 
• 141699-59-4 1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate 
• 106-53-6 para-bromobenzenethiol 

Downstream Products

• 285995-07-5 4-(4-Bromophenylsulphonyl)-1-(2-fluoro-2-phenylethyl)piperidine 
• 285994-62-9 4-(4-cyanophenylsulphonyl)-1-[2-(2,4-difluorophenyl)ethyl]piperidine 
• 285995-02-0 N-(2,4-difluorophenethyl) 4-(4-bromophenylsulfonyl)piperidine 

Relevant academic research and scientific papers

Phenylsulphonyl derivatives as 5-HT receptor ligands

A class of phenylsulphonyl derivatives wherein the sulphonyl moiety is also attached to an N-arylalkyl-substituted azetidine, pyrrolidine or piperidine ring are selective antagonists of the human 5-HT2Areceptor and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of adverse conditions of the central nervous system, including schizophrenia and depression.

4-(Phenylsulfonyl)piperidines: Novel, selective, and bioavailable 5-HT2A receptor antagonists

On the basis of a spirocyclic ether screening lead, a series of acyclic sulfones have been identifed as high-affinity, selective 5-HT2A receptor antagonists. Bioavailability lacking in the parent, 1-(2-(2,4-difluorophenyl)ethyl)-4-(phenylsulfon