496930-00-8

Upstream product

• 496-15-1 1-indoline 
• 51417-51-7 7-bromo-1H-indole 
• 2861-59-8 N-formylindoline 
• 75816-18-1 N-acetyl-7'-bromo-DL-tryptophan 
• 577-19-5 2-nitrophenyl bromide 
• 62813-85-8 7-bromo-2,3-dihydroindole 
• 501-53-1 benzyl chloroformate 
• 496929-99-8 7'-bromo-D-tryptophan 
• 910808-42-3 7-bromo-N-formylindoline 

Relevant academic research and scientific papers

Preparation of 7-halo-indoles by thallation of N-formylindoline and their attempted use for synthesis of the right-hand segment of chloropeptin

7-Substituted (Cl, Br, I) indoles were synthesized by using thallation of N-formylindoline as a key reaction. Two precursor tripeptides for the right-hand segment of chloropeptin were synthesized by using (R)-7′-iodo and 7′-bromotryptophans derived from each 7-substituted indole (I, Br) obtained by the above procedure.

Convenient synthesis of 7′ and 6′-bromo-D-tryptophan and their derivatives by enzymatic optical resolution using D-aminoacylase

Compounds 7′ and 6′-bromo-D-tryptophan (1 and 2) which are important derivatives for the synthesis of the chloropeptin and kistamycin A, respectively, were conveniently synthesized by optical resolution from N-acetyl-7′ and 6′-bromo-DL-tryptophan ((RS)-5 and (RS)-14) using D-aminoacylase.