28749-00-0

Usage

Chemical structure

The compound has a cyclopentapyrazole core structure with a phenyl group attached.

Synthetic compound

It is a synthetic compound, meaning it is created through chemical synthesis rather than being naturally occurring.

Pharmacological properties

It has been studied for its potential effects on the central nervous system.

Therapeutic applications

Research suggests it may have potential therapeutic applications in the treatment of neurological disorders.

Further studies needed

More research is required to better understand its specific mechanisms of action and potential uses.

Medicinal chemistry and drug development

It may have applications in these fields due to its unique chemical structure and potential pharmacological properties.

Scientific investigation

The compound shows promise for further scientific investigation into its properties and potential applications.

Potential fields of application

It may be useful in various fields, including the treatment of neurological disorders and drug development.

InChI:InChI=1/C12H12N2/c1-2-5-9(6-3-1)12-10-7-4-8-11(10)13-14-12/h1-3,5-6H,4,7-8H2,(H,13,14)

Upstream product

• 98815-42-0 2-(α-aminobenzylidene)cyclopentanone 
• 7148-07-4 1-pyrrolidinocyclopent-1-ene 
• 95793-09-2 5-methyl-2-phenyl-1,3,4-oxadiazin-6-one 
• 97130-05-7 Phenyl-{[1-phenyl-1-(2-pyrrolidin-1-yl-cyclopent-1-enyl)-meth-(E)-ylidene]-hydrazono}-acetic acid 
• 120-92-3 cyclopentanone 
• 36150-58-0 2-benzoylcyclopentanone 
• 98-88-4 benzoyl chloride 
• 2941-29-9 2-oxocyclopentanecarbonitrile 
• 63617-45-8 2,5-diphenyl-6H-1,3,4-oxadiazin-6-one 
• 100-52-7 benzaldehyde 
• 4980-23-8 cyanoacetic acid cyclopentylidene hydrazide 
• 93188-39-7 2-Benzoyl-cyclopentan-1-on-exo-semicarbazon 
• 88611-35-2 2-(α-amino-benzylidene)-cyclopentanone 
• 563-41-7 semicarbazide hydrochloride 

Downstream Products

• 172479-27-5 CH(C₁₂H₁₁N₂)3 
• 1569280-15-4 C₁₈H₁₇N₃O₂S 
• 1204771-97-0 C₁₆H₁₃N₃O₂S 

Relevant academic research and scientific papers

A New Synthesis for 1,2,4-Triazolo[1,5-a]-pyridines and 1,2,4-Triazolo[1,5-a]isoquinolines

Condensation of cyano acid hydrazide 1 with cyclopentanone in refluxing ethanolic piperidine yields hydrazone 2. With mixtures of aliphatic aldehydes and different active methylene reagents, 2 reacts to 1,2,4-triazolo[1,5-a]pyridines (8a-f). Compound 2 also reacts with arylidenes 9a-g to give triazolopyridines 10a-g. Reaction of 2 with aromatic aldehydes affords compounds 13a-c. Diazotation of 2 with aryldiazonium chloride in ethanol at 0°C leads to the azo adducts 15a-d. The thieno-1,2,4-triazolopyridine 16 is obtained by reaction of 8a with elementary sulfur. 16 undergoes cycloaddition with ω-nitrostyrene, maleic anhydride, N-arylmalemide, and acrylonitrile yielding the isoquinolines 21-24. All new compounds have been characterized by their IR, 1H NMR, and mass spectra.

Discovery of 2-(1H-indazol-1-yl)-thiazole derivatives as selective EP 1 receptor antagonists for treatment of overactive bladder by core structure replacement

We have designed a series of potent EP1 receptor antagonists. These antagonists are a series of 2-(1H-indazol-1-yl)-thiazoles in which the core structure was replaced with pyrazole-phenyl groups. In preliminary conscious rat cystometry experiments, two representative candidates, 2 and 22, increased bladder capacity. In particular, the increase using 22 was approximately 2-fold that of the baseline. More detailed profiling of this compound and further optimization of this series promises to provide a novel class of drug for treating overactive bladder (OAB).

New synthesis for 1,2,4-triazolo[1,5-a]pyridines and new 1,2,4-triazolo[1,5-a]isoquinolines

Synthesis of 1,2,4-triazolo[1,5-a]pyridines and 1,2,4-triazolo[1,5-a]isoquinolines is presented.

Diels-alder cycloadditions of 1,3,4,-oxadiazin-6-ones with electron rich pi systems

A study of the cycloaddition behavior of several 2,5-disubstituted 1,3,4-oxadiazin-6-ones with electron rich pi bonds has been carried out. trans-1-Propenylpyrrolidine was found to react with the oxadiazinone ring system to give rise to a ring opened diazatrienyl substituted carboxylic acid. Further heating of the acid results in decarboxylation, hydrolysis, cyclization and pyrrolidine elimination to produce a disubstituted pyrazole. Reaction with the trisubstituted enamine 1 - ( 2 - methyl-propenyl) pyrrolidine, was also studied in some detail. The cycloadditions encountered can be rationalized as proceeding by an initial Diels-Alder reaction followed by cheletropic extrusion of nitrogen to produce a ketoketene intermediate. The fate of the ketene is markedly dependent upon the overall pattern of substitution. Some of the products formed can be explained in terms of a competitive migration of the pyrrolidino group to the ketene and benzoyl groups. With one system the major cycloadduct is derived from the Diels-Alder reaction of a transient azaketene tautomer formed by an electrocyclic opening of the oxadiazinone ring.