288251-69-4

Upstream product

• 81329-31-9 1-(4-fluorophenyl)-1H-pyrrole 
• 371-40-4 4-fluoroaniline 
• 169036-71-9 1-(4-fluorophenyl)-2-formylpyrrole 
• 50634-05-4 2,5-dimethoxy-3-tetrahydrofurancarboxaldehyde 

Downstream Products

• 288250-76-0 N-[3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl]-1-(4-fluorophenyl)pyrrole-3-carboxamide 
• 288249-80-9 N-[3-cyano-4-piperidinophenyl]-1-(4-fluorophenyl)pyrrole-3-carboxamide 
• 288249-65-0 N-[3-cyano-4-(2,2,2-trifluoroethyl)phenyl]-1-(4-fluorophenyl)pyrrole-3-carboxamide 
• 288251-68-3 1-(4-fluorophenyl)pyrrole-3-carboxylic acid 
• 691863-10-2 methanesulfonic acid 3-[1-(4-fluoro-phenyl)-1H-pyrrol-3-yl]-2-oxo-oxazolidin-5-ylmethyl ester 
• 691863-22-6 5-azidomethyl-3-[1-(4-fluoro-phenyl)-1H-pyrrol-3-yl]-oxazolidin-2-one 
• 691862-86-9 [1-(4-fluoro-phenyl)-1H-pyrrol-3-yl]-carbamic acid benzyl ester 
• 691863-34-0 5-aminomethyl-3-[1-(4-fluoro-phenyl)-1H-pyrrol-3-yl]-oxazolidin-2-one 
• 691862-98-3 3-[1-(4-fluoro-phenyl)-1H-pyrrol-3-yl]-5-hydroxymethyl-oxazolidin-2-one 

Relevant academic research and scientific papers

AMIDOPYRIDINE DERIVATIVE, AND USE THEREOF

The present invention relates to novel amidopyridine derivatives. More specifically, the present invention provides a medicinal agent which is useful as a prophylactic or therapeutic agent for diseases based on the production of cytokines from T cells, comprising as the active ingredient an amidopyridine derivative or a pharmacologically acceptable salt thereof. Provided are an amidopyridine derivative of the following general formula (I): wherein each symbol has the same meaning as defined in the description, or a pharmacologically acceptable salt thereof.

Synthesis and in vitro antimycobacterial activity of novel 3-(1H-pyrrol-1-yl)-2-oxazolidinone analogues of PNU-100480

Pursuing our search program for new antitubercular drugs we decided to explore the potentiality of oxazolidinone moiety by synthesizing novel 3-(1H-pyrrol-1-yl)-2-oxazolidinone analogues of PNU-100480. The new derivatives were tested against atypical mycobacteria as well as against drug resistant Mycobacterium tuberculosis and some of them exhibited a fairly good activity against Mycobacterium avium complex (MAC).

Novel HIV-1 protease inhibitors active against multiple PI-Resistant viral strains: Coadministration with indinavir

HIV-1 protease inhibitors (PI) with an N-arylpyrrole moiety in the P 3 position afforded excellent antiviral potency and substantially improved aqueous solubility over previously reported variants. The rapid in vitro clearance of these compounds in human liver microsomes prompted oral coadministration with indinavir to hinder their metabolism by the cyctochrome P450 3A4 isozyme and allow for in vivo PK assessment.

AMIDE COMPOUNDS AND MEDICINAL USE THEREOF

The present invention relates to a compound of the formula wherein R1 is substituted aryl, heteroaryl and the like, R2 and R3 are hydrogen, alkyl, halogen, hydroxyl group and the like, Q is N, CH and the like, W is hydrogen, alkyl, hydroxycarbonylalkyl and the like, X is halogen, cyano, nitro, amino and the like, X' is hydrogen, halogen, cyano, nitro, and Y is alkyl, hydroxyl group, alkoxy, mercapto and the like and a salt thereof, and a medicine containing the said compound. The compound of the present invention shows a superior inhibitory effect on activated lymphocytes proliferation and is useful as an agent for the prophylaxis or treatment of various autoimmune diseases.