288252-06-2

Basic information

• Product Name: 2-cyclohexyloxy-5-nitro-benzonitrile
• CAS NO: 288252-06-2
• Molecular Weight: 246.266
• Mol File: 288252-06-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-cyclohexyloxy-5-nitro-benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-cyclohexyloxy-5-nitro-benzonitrile(288252-06-2)
• EPA Substance Registry System: 2-cyclohexyloxy-5-nitro-benzonitrile(288252-06-2)

Safety Data

• Hazardous Substances Data: 288252-06-2(Hazardous Substances Data)

Upstream product

• 2516-96-3 2-chloro-5-nitrobenzoic acid 
• 16588-15-1 2-chloro-5-nitro-benzamide 
• 39835-09-1 5-nitro-2-hydroxybenzonitrile 
• 611-20-1 salicylonitrile 
• 16588-02-6 4-chloro-3-cyanonitrobenzene 
• 108-93-0 cyclohexanol 

Downstream Products

• 288252-05-1 5-amino-2-cyclohexyloxybenzonitrile 

Relevant articles and documents

Design, synthesis, and biological evaluation of 5-(4-(pyridin-4-yl)-1H-1,2,3-triazol-1-yl)benzonitrile derivatives as xanthine oxidase inhibitors

A series of 5-(4-(pyridin-4-yl)-1H-1,2,3-triazol-1-yl)benzonitrile derivatives (1a–p) was designed, synthesized, and identified as xanthine oxidase inhibitors with micromolar level potencies. Among them, the most promising compounds 1j and 1k were obtained with IC50 values of 8.1 and 6.7?μm, respectively. The Lineweaver–Burk plot revealed that compound 1k acted as a mixed-type xanthine oxidase inhibitor. SAR analysis revealed that a carbon atom occupying the X3 position is not as effective as a nitrogen atom, and an iso-pentyloxy or a cyclopentyloxy at the 2-position of benzonitrile moiety will benefit the inhibitory potency. The basis of xanthine oxidase inhibition by 1k was rationalized by molecular modeling studies.