2885-39-4

Basic information

• Product Name: Acetoxycycloheximide
• Synonyms: Acetoxycycloheximide;Antibiotic SF-2441;AXM;NSC-32743;Streptovitacin E 73;2,6-Piperidinedione, 4-[2-[5-(acetyloxy)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]-, [1S-[1.alpha.(S*),3.alpha.,5.alpha.]]-;2,6-Piperidinedione, 4-[2-[5-(acetyloxy)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]-, [1S-[1.alpha.(S*),3.beta.,5.beta.]]-;Acetyloxycycloheximide
• CAS NO: 2885-39-4
• Molecular Formula: C₁₇H₂₅NO₆
• Molecular Weight: 339.385
• Mol File: 2885-39-4.mol
• Article Data: 1

Chemical Properties

• Melting Point: 140°C
• Boiling Point: 475.36°C (rough estimate)
• Flash Point: 274°C
• Appearance: /
• Density: 1.1256 (rough estimate)
• Vapor Pressure: 2.03E-13mmHg at 25°C
• Refractive Index: 1.5420 (estimate)
• CAS DataBase Reference: Acetoxycycloheximide(CAS DataBase Reference)
• NIST Chemistry Reference: Acetoxycycloheximide(2885-39-4)
• EPA Substance Registry System: Acetoxycycloheximide(2885-39-4)

Safety Data

• Hazardous Substances Data: 2885-39-4(Hazardous Substances Data)

Usage

Safety Profile

Deadly poison by ingestion,intravenous, intraperitoneal, and subcutaneous routes.Humanmutation data reported. When heated todecomposition it emits toxic fumes such as NOx.

InChI:InChI=1/C17H25NO6/c1-9-7-17(3,24-10(2)19)8-12(16(9)23)13(20)4-11-5-14(21)18-15(22)6-11/h9,11-13,20H,4-8H2,1-3H3,(H,18,21,22)/t9-,12-,13+,17+/m0/s1

Upstream product

• 131057-04-0 Acetic acid (1R,3S,5S)-3-[(R)-2-(2,6-dioxo-piperidin-4-yl)-1-triethylsilanyloxy-ethyl]-1,5-dimethyl-4-oxo-cyclohexyl ester 
• 60739-53-9 4-(tetrahydro-2H-pyran-2-yloxy)cyclohexanone 
• 89794-52-5 1-methyl-1,4-cyclohexanediol 
• 17429-02-6 4-hydroxy-4-methylcyclohexanone 
• 13482-22-9 4-hydroxycyclohexanone 
• 131057-03-9 1-methyl-4-tetrahydropyranyloxy-1-cyclohexanol 
• 131077-78-6 4-methyl-4-(trimethylsilyloxy)cyclohexanone 
• 131057-05-1 4-[(R)-2-((1S,3S,5R)-5-Hydroxy-3,5-dimethyl-2-oxo-cyclohexyl)-2-triethylsilanyloxy-ethyl]-piperidine-2,6-dione 
• 131077-79-7 trans-2,4-dimethyl-4-trimethylsiloxy-1-cyclohexanone 
• 523-86-4 (+/-)-4-<2-(5-hydroxy-3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl>-2,6-piperidindione 
• 131077-81-1 4-[2-((3R,5S)-3,5-Dimethyl-2-oxo-5-trimethylsilanyloxy-cyclohexyl)-2-hydroxy-ethyl]-piperidine-2,6-dione 

Related news

Aversive effects and retention impairment induced by Acetoxycycloheximide (cas 2885-39-4) in an instrumental task07/18/2019

AXM, when subcutaneously injected during the first 3 min following the acquisition of a nondiscriminative instrumental learning task, induced an aversion for the food reinforcement which had been associated with the training situation and with the pharmacological treatment. The high number of no...detailed

Acetoxycycloheximide (cas 2885-39-4) (E-73) rapidly induces apoptosis mediated by the release of cytochrome c via activation of c-Jun N-terminal kinase07/17/2019

Cycloheximide (CHX) is an inhibitor of protein synthesis and commonly used to modulate death receptor-mediated apoptosis or to induce apoptosis in a number of normal and transformed cells. In this study we show that a close structural derivative of CHX, acetoxycycloheximide (E-73) induced rapid ...detailed

Effects of Acetoxycycloheximide (cas 2885-39-4) on the metabolism of hepatic triglycerides in the rat07/16/2019

Acetoxycycloheximide (ACH), the most potent inhibitor of protein synthesis in mammalian tissues, was administered to female rats in order to investigate the relationship of hepatic protein synthesis inhibition to the pathogenesis of fatty liver. Groups of animals were sacrificed at intervals bet...detailed

Effects of Acetoxycycloheximide (cas 2885-39-4) and anisomycin on approach and escape responses to hypothalamic stimulation07/14/2019

The effects of acetoxycycloheximide (AXM) (7 mg/kg) and anisomycin (ANI) (25 and 150 mg/kg) on approach and escape responses induced by hypothalamic stimulation were studied in a situation in which male Swiss mice could initiate a continuous brain stimulation train by pressing a lever at one end...detailed

Relevant articles and documents

Syntheses and biological activities of (+/-)-streptovitacin A and E-73.

(+/-)-Streptovitacin A (1) and its stereoisomers were synthesized by an aldol reaction of (+/-)-2,4-dimethyl-4-trimethylsiloxy-1-cyclohexanones (4b and 9) with 4-(2-oxoethyl)-2,6-piperidinedione (5). E-72 (2) was derived from synthetic 1. (+/-)-1 showed m