523-86-4

Usage

Uses

Used in Pharmaceutical Industry:
2,6-Piperidinedione, 4-(2-hydroxy-2-(5-hydroxy-3,5-dimethyl-2-oxocyclo hexyl)ethyl)is used as a potential pharmaceutical compound for its unique structural and chemical properties. Its specific application reason is yet to be determined, but its synthesis and structural features suggest it may have potential in the development of new drugs or therapeutic agents.
Used in Industrial Applications:
2,6-Piperidinedione, 4-(2-hydroxy-2-(5-hydroxy-3,5-dimethyl-2-oxocyclo hexyl)ethyl)may also be used in various industrial applications due to its unique chemical properties. The exact application areas are yet to be identified, but its synthesis process and chemical composition indicate it could be utilized in the development of new materials or chemical processes. Further research and studies are needed to fully understand and explore its potential industrial uses.

InChI:InChI=1/C15H23NO5/c1-8-6-15(2,21)7-10(14(8)20)11(17)3-9-4-12(18)16-13(19)5-9/h8-11,17,21H,3-7H2,1-2H3,(H,16,18,19)

Upstream product

• 131077-79-7 trans-2,4-dimethyl-4-trimethylsiloxy-1-cyclohexanone 
• 60739-53-9 4-(tetrahydro-2H-pyran-2-yloxy)cyclohexanone 
• 89794-52-5 1-methyl-1,4-cyclohexanediol 
• 17429-02-6 4-hydroxy-4-methylcyclohexanone 
• 131077-81-1 4-[2-((3S,5S)-3,5-Dimethyl-2-oxo-5-trimethylsilanyloxy-cyclohexyl)-2-hydroxy-ethyl]-piperidine-2,6-dione 
• 131077-81-1 4-[2-((3R,5S)-3,5-Dimethyl-2-oxo-5-trimethylsilanyloxy-cyclohexyl)-2-hydroxy-ethyl]-piperidine-2,6-dione 
• 131077-78-6 4-methyl-4-(trimethylsilyloxy)cyclohexanone 
• 131057-03-9 1-methyl-4-tetrahydropyranyloxy-1-cyclohexanol 
• 13482-22-9 4-hydroxycyclohexanone 
• 131077-79-7 cis-2,4-dimethyl-4-trimethylsiloxy-1-cyclohexanone 
• 1001-75-8 4-methyl-4-pentenoic acid 
• 1149347-46-5 3-[(dodecylthio-carbonyl)-methyl]-glutarimide 
• 66-81-9 Cycloheximide 

Downstream Products

• 4348-89-4 4-(2-hydroxy-3,5-dimethyl-phenethyl)-piperidine-2,6-dione 
• 131057-05-1 4-[(R)-2-((1S,3S,5R)-5-Hydroxy-3,5-dimethyl-2-oxo-cyclohexyl)-2-triethylsilanyloxy-ethyl]-piperidine-2,6-dione 
• 2885-39-4 (+/-)-E-73 
• 131057-04-0 Acetic acid (1R,3S,5S)-3-[(R)-2-(2,6-dioxo-piperidin-4-yl)-1-triethylsilanyloxy-ethyl]-1,5-dimethyl-4-oxo-cyclohexyl ester 

Relevant academic research and scientific papers

Versatile Synthetic Route to Cycloheximide and Analogues That Potently Inhibit Translation Elongation

Cycloheximide (CHX) is an inhibitor of eukaryotic translation elongation that has played an essential role in the study of protein synthesis. Despite its ubiquity, few studies have been directed towards accessing synthetic CHX derivatives, even though such efforts may lead to protein synthesis inhibitors with improved or alternate properties. Described here is the total synthesis of CHX and analogues, and the establishment of structure–activity relationships (SAR) responsible for translation inhibition. The SAR studies aided the design of more potent compounds, one of which irreversibly blocks ribosomal elongation, preserves polysome profiles, and may be a broadly useful tool for investigating protein synthesis.

Remote Oxidation of Aliphatic C-H Bonds in Nitrogen-Containing Molecules

Nitrogen heterocycles are ubiquitous in natural products and pharmaceuticals. Herein, we disclose a nitrogen complexation strategy that employs a strong Bronsted acid (HBF4) or an azaphilic Lewis acid (BF3) to enable remote, non-directed C(sp3)-H oxidations of tertiary, secondary, and primary amine- and pyridine-containing molecules with tunable iron catalysts. Imides resist oxidation and promote remote functionalization.

Syntheses and biological activities of (+/-)-streptovitacin A and E-73.

(+/-)-Streptovitacin A (1) and its stereoisomers were synthesized by an aldol reaction of (+/-)-2,4-dimethyl-4-trimethylsiloxy-1-cyclohexanones (4b and 9) with 4-(2-oxoethyl)-2,6-piperidinedione (5). E-72 (2) was derived from synthetic 1. (+/-)-1 showed m