2890-73-5

Upstream product

• 2015-19-2 5-amino-2-chlorobenzenesulfonamide 
• 108-24-7 acetic anhydride 
• 4533-95-3 5-nitro-2-chlorobenzenesulfonyl chloride 
• 100-00-5 4-chlorobenzonitrile 
• 946-30-5 2-chloro-5-nitrobenzenesulphonic acid sodium salt 
• 96-72-0 2-chloro-5-nitrobenzenesulfonamide 
• 96-73-1 2-chloro-5-nitro-benzenesulfonic acid 
• 75-36-5 acetyl chloride 

Relevant academic research and scientific papers

Controllable Effect of Structural Modification of Sulfonylurea Herbicides on Soil Degradation

The study of soil degradation behaviors of sulfonylurea herbicides in relation to their different structural attributes is utmost important for us to comprehend the development of new eco-friendly herbicides. It is postulated that the structural modification of the chemical structures could influence their degradation rates in soil. Nine devised structures were synthesized to study their herbicidal activity as well as their soil degradation behaviors respectively. The novel compounds I-3–I-7 were characterized by UV,1H NMR and13C NMR, MS and EA. Bioassays indicated that most of target compounds displayed superior herbicidal activities in comparison with Chlorsulfuron. Soil degradation results further confirmed our previous assumption that the introduction of electron-donating substituents at 5thposition of the benzene ring distinctly increased their degradation rates, among which dimethylamino and diethylamino groups can adjust the degradation rate to a more favorable status.

Synthesis and evaluation of novel monosubstituted sulfonylurea derivatives as antituberculosis agents

A series of novel monosubstituted sulfonylurea derivatives 10a-y were synthesized and characterized by 1H NMR, 13C NMR and HRMS. These compounds were evaluated against Mycobacterium tuberculosis H37Rv in vitro. The results showed compounds 10f, 10k and 10s exhibited moderate antituberculosis activities with MIC values in the range of 20-100 mg/L. Compounds 10b and 10o displayed good antituberculosis activities (MIC 10 mg/L), which were comparable with that of the sulfometuron methyl. Both of the two compounds showed little cytotoxicities, with an IC50 against THP-1 cells greater than 100 mg/L.