2892-27-5

Basic information

• Product Name: 1-Propanone, 1-(3-chloro-4-hydroxyphenyl)-
• Synonyms: 1-Propanone, 1-(3-chloro-4-hydroxyphenyl)-;3-Chloro-4-hydroxypropiophenone
• CAS NO: 2892-27-5
• Molecular Formula: C₉H₉ClO₂
• Molecular Weight: 184.62
• Mol File: 2892-27-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 114.5–115.5°C
• Boiling Point: 323.7°C at 760 mmHg
• Flash Point: 149.6°C
• Appearance: /
• Density: 1.248g/cm³
• Vapor Pressure: 0.000136mmHg at 25°C
• Refractive Index: 1.558
• CAS DataBase Reference: 1-Propanone, 1-(3-chloro-4-hydroxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 1-(3-chloro-4-hydroxyphenyl)-(2892-27-5)
• EPA Substance Registry System: 1-Propanone, 1-(3-chloro-4-hydroxyphenyl)-(2892-27-5)

Safety Data

• Hazardous Substances Data: 2892-27-5(Hazardous Substances Data)

Usage

Preparation

Preparation by Fries rearrangement of o-chlorophenyl propio nate with aluminium chloride, at 165° for 1 h (98%) or at 110° for 2 h (63%) Preparation by demethylation of 3-chloro-4-methoxy-propiophenone (m.p. 88°) (m.p. 89–90°) with refluxing pyridinium chloride for 15 min (75%) Preparation by diazotization of 3-amino-4-hydroxypropiophenone, followed by decomposition of the diazonium salt obtained (52%) Preparation by chlorination of p-hydroxypropiophenone with chlorine in cooled acetic acid (57%).

InChI:InChI=1/C9H9ClO2/c1-2-8(11)6-3-4-9(12)7(10)5-6/h3-5,12H,2H2,1H3

Upstream product

• 70-70-2 4-hydroxypropiophenone 
• 2420-16-8 4-hydroxy-3-chlorobenzaldehyde 
• 95-57-8 2-monochlorophenol 
• 766-51-8 2-Chloroanisole 
• 79-03-8 propionyl chloride 
• 7446-70-0 aluminium trichloride 
• 60202-89-3 2-chlorophenyl propionate 
• 4394-54-1 1-(3'-chloro-4'-methoxyphenyl)-1-propanone 

Downstream Products

• 1939-80-6 1-[3-Chloro-4-(2,3-dihydroxy-propoxy)-phenyl]-propan-1-one 
• 80762-29-4 ethyl (2-chloro-4-propionylphenoxy)acetate 

Relevant articles and documents

NOVEL OLEFIN DERIVATIVE

The object of the present invention is to provide novel compounds having ACC2 inhibiting activity. In addition, the object of the present invention is to provide a pharmaceutical composition comprising the compound. A compound of formula (I′): wherein R1 is substituted or unsubstituted aryl etc., R2 is each independently hydrogen, substituted or unsubstituted alkyl etc., R3 is each independently hydrogen, substituted or unsubstituted alkyl etc., n is an integer from 0 to 3, R12 is hydrogen, substituted or unsubstituted alkyl etc., Ring A is aromatic carbocycle or aromatic heterocycle, R9 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl etc., m is an integer from 0 to 4, R4 and R5 is each independently hydrogen, substituted or unsubstituted alkyl etc., R6 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl etc., R13 is hydrogen, substituted or unsubstituted alkyl etc., X5 is bond etc., R7 is hydrogen or substituted or unsubstituted alkyl, R8 is substituted or unsubstituted alkylcarbonyl, substituted or unsubstituted alkenylcarbonyl etc.

Compounds and methods of making same

A radioimmunoassay procedure has been discovered for bupropion [(±)-2-t-butylamino-3-chloropropiophenone], an antidepressant compound, in biological fluids. Novel compounds of formula STR1 wherein either R2 is oxygen and R1 is (CHsu