2896-66-4

Upstream product

• 7452-10-0 2-hydroxy-3-methoxy-5-methylbenzaldehyde 
• 15191-36-3 2-bromo-4,6-dimethylphenol 
• 124-41-4 sodium methylate 
• 875845-99-1 2-(2-hydroxy-3,5-dimethyl-phenoxy)-5-nitro-benzophenone 
• 408337-66-6 2-(2,4-dimethyl-phenoxy)-5-nitro-benzophenone 
• 854037-93-7 2-(3,5-dimethyl-phenoxy)-5-nitro-benzophenone 
• 408337-70-2 2-(2-hydroxy-4,6-dimethyl-phenoxy)-5-nitro-benzophenone 
• 7452-08-6 2-Hydroxy-3-methoxy-5-methylbenzylalkohol 
• 67-56-1 methanol 
• 4370-49-4 3,5-dimethyl-3,5-cyclohexadiene-1,2-dione 
• 855462-54-3 2-(2-methoxy-4,6-dimethyl-phenoxy)-5-nitro-benzophenone 
• 18087-07-5 2,4-dimethyl-6-methoxyaniline 
• 2931-90-0 5-formylvanillin 

Downstream Products

• 32263-14-2 4-hydroxy-3-methoxy-5-methylbenzaldehyde 
• 58245-81-1 2,4-Dimethoxy-4,6-dimethyl-2,5-cyclohexadienon 

Relevant academic research and scientific papers

First total syntheses of (±)-penicillones A and B

(Chemical Equation Presented) The first total syntheses of (±)-penicillones A (1) and B (2) have been accomplished from 2-methoxy-4,6-dimethylphenol (7) in 9 and 8 synthetic steps, respectively. Intramolecular Diels-Alder reaction of masked o-benzoquinone

Catalytic Hydrogenolysis of Substituted Diaryl Ethers by Using Ruthenium Nanoparticles on an Acidic Supported Ionic Liquid Phase (Ru@SILP-SO3H)

Catalytic hydrogenolysis of diaryl ethers is achieved by using ruthenium nanoparticles immobilized on an acidic supported ionic liquid phase (Ru@SILP-SO 3 H) as a multifunctional catalyst. The catalyst components are assembled through a molecular approach ensuring synergistic action of the metal and acid functions. The resulting catalyst is highly active for the hydrogenolysis of various diaryl ethers. For symmetric substrates such as diphenyl ether, hydrogenolysis is followed by full hydrodeoxygenation producing the corresponding cycloalkanes as the main products. For unsymmetric substrates, the cleavage of the C-O bond is regioselective and occurs adjacent to the unsubstituted phenyl ring. As hydrogenation of benzene is faster than hydrodeoxygenation over the Ru@SILP-SO 3 H catalyst, controlled mixtures of cyclohexane and substituted phenols are accessible with good selectivity. Application of Ru@SILP-SO 3 H catalyst in continuous-flow hydrogenolysis of 2-methoxy-4-methylphenoxybenzene is demonstrated with use of commercial equipment.

A highly efficient approach to vanillin starting from 4-cresol

A highly efficient approach to the famous flavor and fragrance compound vanillin has been developed starting from 4-cresol with the attention focused on improving the sustainability of all the reactions. The approach involves a three-step sequence of the quasi-quantitative selective clean oxybromination of 4-cresol, the high-yield selective aerobic oxidation of 2-bromo-4-cresol, and the quantitative methoxylation of 3-bromo-4-hydroxybenzaldehyde with the recovery of pure methanol. Herein, the pivotal oxidation and methoxylation reactions are logically investigated and developed into two concise methodologies. As a green alternative, the approach holds significant value for the sustainable manufacturing of vanillin. the Partner Organisations 2014.

Tobacco smoke chemistry. 2. Alkyl and alkenyl substituted guaiacols found in cigarette smoke condensate.

A series of alkyl and alkenyl substituted guaiacols, which comprise a group of biologically and organoleptically active compounds, have been synthesized. Mass spectra and GC retention times for these have been recorded and compared with those obtained for constituents of a weakly acidic fraction of smoke condensate derived from American blend type cigarettes. On the basis of these results, 25 guaiacols have been identified, 18 of which have not been detected in tobacco smoke condensate previously.