2924-75-6

Basic information

• Product Name: 1-(ethylsulfanyl)-4-fluorobenzene
• Synonyms: 1-(Ethylsulfanyl)-4-fluorobenzene; Benzene, 1-(ethylthio)-4-fluoro-; Ethyl 4-fluorophenyl sulfide
• CAS NO: 2924-75-6
• Molecular Formula: C₈H₉FS
• Molecular Weight: 156.2205
• Mol File: 2924-75-6.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 205.1°C at 760 mmHg
• Flash Point: 77.8°C
• Density: 1.1g/cm³
• Vapor Pressure: 0.365mmHg at 25°C
• Refractive Index: 1.535
• CAS DataBase Reference: 1-(ethylsulfanyl)-4-fluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(ethylsulfanyl)-4-fluorobenzene(2924-75-6)
• EPA Substance Registry System: 1-(ethylsulfanyl)-4-fluorobenzene(2924-75-6)

Safety Data

• Hazardous Substances Data: 2924-75-6(Hazardous Substances Data)

Usage

General Description

1-(ethylsulfanyl)-4-fluorobenzene is a chemical compound with the molecular formula C8H9FS. It is an aromatic compound that consists of a benzene ring with a fluorine atom and an ethylsulfanyl group attached to it. 1-(ethylsulfanyl)-4-fluorobenzene is used in organic synthesis and can serve as a building block for the synthesis of various pharmaceuticals and agrochemicals. It is also used as a precursor in the manufacture of dyes, fragrances, and other fine chemicals. The presence of the fluorine atom and the ethylsulfanyl group in the compound gives it unique chemical properties, making it valuable in a variety of industrial applications.

Upstream product

• 352-34-1 4-fluoro-1-iodobenzene 
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• 74-88-4 methyl iodide 

Relevant articles and documents

PYRAZOLYL COMPOUNDS AND METHODS OF USE THEREOF

Compounds having activity as chemotherapeutic agents are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, stereoisomer, isotopic form or prodrug thereof, wherein R1a, R1b, R1c, R1d, L, and are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods for treating cancer (e.g., hematological cancers) are also provided.

Bromine structural domain inhibitor compound and application thereof

The invention relates to a bromine structural domain inhibitor and provides a compound shown in a general formula I, pharmaceutical salt, an enantiomer, a diastereoisomer, an atropisomer, racemate, apolymorphic substance and solvate of the compound or an isotope labelled compound (including a deuterium substituted compound), a preparation method of the compound, pharmaceutical composition containing the compound and an application of the above components in pharmaceuticals.

The influence of electronic perturbations on the Sulfur-Fluorine Gauche Effect Dedicated to Prof. Dr. Antonio Togni on the occasion of his 60th birthday.

Herein, a solution phase NMR conformer population analysis is employed to probe the effect of remote electronic perturbations on the conformational equilibria of a series of para-substituted β-fluorosulfides (1), sulfoxides (2) and sulfone derivatives (3). Conformations that allow for stabilizing stereoelectronic (σC-H → σ?C-F) and electrostatic (Fδ-...Sδ+) interactions predominate: this is consistent with the Sulfur-Fluorine Gauche Effect. The molar fractions (χ) of the two possible gauche conformers correlate linearly with the electron-withdrawing aptitude of the para-substituent, rendering the system ideally suited for a Hammett-type analysis. Despite the clear influence that the remote para-substituents have on conformer population, this is superseded by the oxidation state on sulfur (II, IV, VI), where an increased preference for the gauche conformer follows the trend: sulfide sulfone sulfoxide. It is envisaged that this proof of concept in controlling conformer population, either by proximal (oxidation state) or remote tuning (para-substituent), will find application in molecular design.