29263-67-0

Basic information

• Product Name: 2-Pyridinemethanol, a-(4-methylphenyl)-
• CAS NO: 29263-67-0
• Molecular Formula: C13H13NO
• Molecular Weight: 199.252
• Mol File: 29263-67-0.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: 2-Pyridinemethanol, a-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinemethanol, a-(4-methylphenyl)-(29263-67-0)
• EPA Substance Registry System: 2-Pyridinemethanol, a-(4-methylphenyl)-(29263-67-0)

Safety Data

• Hazardous Substances Data: 29263-67-0(Hazardous Substances Data)

Upstream product

• 98-98-6 2-Picolinic acid 
• 104-87-0 4-methyl-benzaldehyde 
• 21970-13-8 (pyridin-2-yl)magnesium bromide 
• 29335-87-3 2-(4-methyl-benzyl)-pyridine 
• 78539-88-5 2-(4-toluoyl)pyridine 
• 106-38-7 para-bromotoluene 
• 100-70-9 2-Cyanopyridine 
• 1121-60-4 pyridine-2-carbaldehyde 
• 108-88-3 toluene 
• 109-04-6 2-bromo-pyridine 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 67-68-5 dimethyl sulfoxide 

Downstream Products

• 29335-87-3 2-(4-methyl-benzyl)-pyridine 
• 75343-78-1 Piperidin-2-yl-p-tolyl-methanol 
• 75343-78-1 Piperidin-2-yl-p-tolyl-methanol 
• 78539-88-5 2-(4-toluoyl)pyridine 
• 109810-35-7 phenyl(pyridin-2-yl)(p-tolyl)methanol 
• 59742-89-1 3-(4-methylphenyl)-[1,2,3]triazolo[1,5-a]pyridine 
• 59742-92-6 2-pyridyl 4-tolyl ketone hydrazone 
• 1353686-80-2 C₁₅H₁₇NO 
• 1353686-75-5 8a-(p-tolyl)indolizinone 
• 1353686-69-7 C₁₅H₁₃NO 
• 782504-65-8 2-[(4-methylphenyl)methyl]piperidine hydrochloride 

Relevant articles and documents

Green synthesis method of polyaryl substituted methanol

The invention relates to a green synthesis method of polyaryl substituted methanol, in particular to a method for efficiently synthesizing polyaryl substituted methanol in a polar aprotic solvent under the condition of an oxidizing agent by taking polyaryl substituted methane as a raw material and alkali as an additive. The method provided by the invention is green and environment-friendly, avoids using expensive metal catalysts, and has the advantages of low cost, few reaction steps, short time, high yield and the like.

Targeting the aryl hydrocarbon receptor with a novel set of triarylmethanes

The aryl hydrocarbon receptor (AhR) is a chemical sensor upregulating the transcription of responsive genes associated with endocrine homeostasis, oxidative balance and diverse metabolic, immunological and inflammatory processes, which have raised the pharmacological interest on its modulation. Herein, a novel set of 32 unsymmetrical triarylmethane (TAM) class of structures has been synthesized, characterized and their AhR transcriptional activity evaluated using a cell-based assay. Eight of the assayed TAM compounds (14, 15, 18, 19, 21, 22, 25, 28) exhibited AhR agonism but none of them showed antagonist effects. TAMs bearing benzotrifluoride, naphthol or heteroaromatic (indole, quinoline or thiophene) rings seem to be prone to AhR activation unlike phenyl substituted or benzotriazole derivatives. A molecular docking analysis with the AhR ligand binding domain (LBD) showed similarities in the binding mode and in the interactions of the most potent TAM identified 4-(pyridin-2-yl (thiophen-2-yl)methyl)phenol (22) compared to the endogenous AhR agonist 5,11-dihydroindolo[3,2-b]carbazole-12-carbaldehyde (FICZ). Finally, in silico predictions of physicochemical and biopharmaceutical properties for the most potent agonistic compounds were performed and these exhibited acceptable druglikeness and good ADME profiles. To our knowledge, this is the first study assessing the AhR modulatory effects of unsymmetrical TAM class of compounds.

Ligand-Free Iridium-Catalyzed Dehydrogenative ortho C?H Borylation of Benzyl-2-Pyridines at Room Temperature

A convenient and ligand-free iridium-catalyzed dehydrogenative ortho C?H borylation of benzyl-2-pyridines has been developed. The reaction proceeds smoothly at room temperature using pinacolborane as a borylating reagent in the presence of catalytic amount of [IrOMe(COD)]2. The reaction is compatible with many functional groups, providing a vast array of ortho borylated products in moderate to excellent yields with excellent selectivities. (Figure presented.).