29576-16-7

Upstream product

• 201230-82-2 carbon monoxide 
• 164527-43-9 phosphoric acid diethyl ester 3-p-tolylallyl ester 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 590-17-0 cyanomethyl bromide 
• 104-87-0 4-methyl-benzaldehyde 
• 1866-39-3 4-methylcinnamic acid 
• 624-75-9 iodoacetonitrile 
• 109-75-1 but-3-enenitrile 
• 539-44-6 N-4-methylphenylhydrazine 
• 459-44-9 4-methylbenzenediazonium tetrafluoroborate 
• 1504-75-2 3-(4-methylphenyl)acrylaldehyde 
• 81981-13-7 3-acetoxy-3-cyano-1-(4-methylphenyl)propene 
• 762-73-2 trimethyl(allyl)stannane 
• 53915-69-8 allenyltributylstannane 

Relevant academic research and scientific papers

Cu-Catalyzed atom transfer radical addition reactions of alkenes with α-bromoacetonitrile

A practical, simple, and efficient copper-catalyzed atom transfer radical addition reaction of alkenes with α-bromoacetonitrile is realized. With this methodology, various γ-bromonitriles and β,γ-unsaturated nitriles were efficiently constructed.

Photo-Promoted Decarboxylative Alkylation of α, β-Unsaturated Carboxylic Acids with ICH2CN for the Synthesis of β, γ-Unsaturated Nitriles

An efficient, catalyst/photocatalyst-free, and cost-effective methodology for the decarboxylative alkylation of α,β-unsaturated carboxylic acids to synthesize β,γ-unsaturated nitriles has been developed. The reaction proceeded in an environmentally benign atmosphere of blue light-emitting diode irradiation with K2CO3 and water at room temperature. The methodology worked for a wide range of substrates (22 examples) with up to 83% yield. The protocol is also compatible for gram-scale synthesis.

Synthesis method of (E)-4-aryl-3-butenonitrile compound

The invention belongs to the technical field of organic synthesis chemistry, and discloses a synthesis method of a (E)-4-aryl-3-butenonitrile compound. According to the method, under catalysis of copper iodide, a target compound is synthesized in one step

Nickel-catalysed novel β,γ-unsaturated nitrile synthesis

Through a nickel-catalysed Heck-type reaction, a direct coupling of alkenes with α-cyano alkyl bromides was achieved. This procedure provides a novel way for the synthesis of β,γ-unsaturated nitriles.

Palladium-catalyzed C-C bond formation of arylhydrazines with olefins via carbon-nitrogen bond cleavage

The unactivated carbon-nitrogen bond of various aryl hydrazines was cleaved under very mild conditions by Pd(0) with the assistance of Pd(II). The in situ generated aryl palladium complex readily takes part in the C-C bond formation with olefins. This study offered a new mode of C-Pd bond formation, which will spur the development of palladium-catalyzed cross-coupling in the future.

Synthesis of allylamides from allyl halides, carbon monoxide, and titanium-nitrogen complexes prepared from molecular nitrogen

4-Phenylbut-3-enamide could be synthesized from corresponding 3-chloroprop-2-enylbenzene, carbon monoxide (1atm), and titanium-nitrogen complexes, prepared from Ti(OiPr)4, Li, TMSCl, and molecular nitrogen (1atm), using a palladium catalyst. The reaction proceeds via transmetalation of the titanium-nitrogen complex to an acylpalladium complex. PtBu3 as a ligand of the palladium catalyst, afforded a good result, and the amounts of Li and TMSCl affected the yield of amide. When the reaction was carried out using a bidentate ligand on the palladium complex under an atmosphere of argon instead of carbon monoxide, an allylamine derivative was obtained.

UNSATURATED OXIME DERIVATIVES AND THE USE THEREOF AS LATENT ACIDS

Compounds of formulae I, II or IIIwherein m is zero or 1; n is 1, 2 or 3; R1 inter alia is unsubstituted or substituted phenyl, or naphthyl, anthracyl, phenanthryl, a heteroaryl radical, or C2-C12alkenyl; R'1 inter alia is vinylene, phenylene, naphthylene

Organotin Nucleophiles. 5. Palladium-Catalyzed Allylic Propargylation with Allenylstannane

Allenyltrialkylstannanes were found to react with various allylic acetates in the presence of catalytic amounts of Pd(PPh3)4 under mild neutral conditions, providing a novel approach for obtaining the 1,5-enyne carbon skeleton.The regioselectivity of propargylation depends largely on the electron-withdrawing properties of the substituents at the two ends of the allylic system: substitution occurs at the end of closer proximity to the more electronegative group.Allylic cyanohydrin acetates are substituted at a position α to the cyano group along with formation of a reduced side product.Several mechanistic aspects of these reactions are discussed.