296776-37-9

Upstream product

• 81-07-2 saccharin 
• 53440-57-6 3-phenylbenzo[d]isothiazole-1,1-dioxide 
• 5669-05-6 1,2-benzoisothiazole 1,1-dioxide 
• 98-80-6 phenylboronic acid 
• 769196-05-6 2-benzylbenzenesulfonamide 
• 100-58-3 phenylmagnesium bromide 
• 136481-64-6 N-tert-butyl-2-(α-hydroxybenzyl)benzenesulphonamide 
• 2512-24-5 N-tert-butylbenzenesulfonamide 
• 100-52-7 benzaldehyde 
• 106380-99-8 1,1-dioxo-3-phenyl-2,3-dihydro-1λ⁶-benz[d]isothiazol-3-ol 
• 124401-11-2 7b-phenyl-7bH-oxazirino<2,3-b><1,2>benzisothiazole 3,3-dioxide 

Relevant academic research and scientific papers

Ni(II)/tBu-SMI-PHOX catalyzed enantioselective addition of arylboronic acids to cyclic N-sulfonyl aldimines

An efficient Ni(ClO4)2·6H2O/SMI-PHOX catalyzed enantioselective addition of arylboronic acids to cyclic N-sulfonyl aldimines is envisioned to afford excellent enantioselectivities (up to 99% ee) in high yields (up to 98%). This protocol offers new opportunities for the synthesis of chiral benzosultams containing a stereogenic tertiary carbon center. The highlights of this method include mild reaction conditions, the use of cheap metal catalyst and a wide substrate scope.

B(C6F5)3-Catalyzed Reduction of Cyclic N-Sulfonyl Ketimines

A metal-free method for reduction of cyclic N-sulfonyl ketimines catalyzed by B(C6F5)3, using commercially available methylphenylsilane as a reducing reagent under mild conditions has been developed. This reductive protoco

Enantioselective Radical Construction of 5-Membered Cyclic Sulfonamides by Metalloradical C-H Amination

Both arylsulfonyl and alkylsulfonyl azides can be effectively activated by the cobalt(II) complexes of D2-symmetric chiral amidoporphyrins for enantioselective radical 1,5-C-H amination to stereoselectively construct 5-membered cyclic sulfonami

Pd/Zn(OTf)2 Co-Catalyzed Asymmetric Hydrogenation of Imines under Normal Pressure of Hydrogen

An efficient method for the asymmetric hydrogenation of cyclic and acyclic N-sulfonylimines co-catalyzed by Pd/Zn(OTf)2 using hydrogen gas under ambient pressure was developed. The methodology offers an easy access to generate chiral sulfonylam

Preparation method for chiral sulfonamide organic compound

The invention discloses a preparation method for a chiral sulfonamide organic compound. The preparation method for the chiral sulfonamide organic compound is characterized in that a sulfonimide compound and hydrogen serve as reaction raw materials, and a

Synthesis of chiral sultams via palladium-catalyzed intramolecular asymmetric reductive amination

A novel palladium-catalyzed intramolecular reductive amination of ketones with weakly nucleophilic sulfonamides has been developed in the presence of a Br?nsted acid, giving a wide range of chiral γ-, δ-, and ε-sultams in high yields and up to 99% of enan

Method for synthesizing chiral amine through palladium catalyzed asymmetric hydrogenolysis of racemic oxazirine

A catalysis system used in a method for synthesizing chiral amine through palladium catalyzed asymmetric hydrogenolysis of racemic oxazirine is a chiral diphosphine complex of palladium. The racemic substituted oxazirine is hydrogenolyzed to obtain corresponding chiral sulfonamide, and the enantiomeric excess can reach 99%. The method has the advantages of simple, practical and easy operation, commercially available catalyst and mild reaction conditions. The method for synthesizing the chiral sulfonamide through asymmetric hydrogenolysis also has the advantages of high antipodal selectivity, good yield, environmentally-friendly and atomically-economic reaction, and environmental protection.

Nickel-catalyzed asymmetric transfer hydrogenation of hydrazones and other ketimines

We report the use of nickel catalysts for the catalytic transfer hydrogenation of hydrazones and other ketimines with formic acid. Strongly donating bisphosphines must be used to support the catalysts. As in enzymatic catalysis, attractive weak interactio

Formal palladium-catalyzed asymmetric hydrogenolysis of racemic N -sulfonyloxaziridines

Highly enantioselective palladium-catalyzed formal hydrogenolysis of racemic N-sulfonyloxaziridines has been realized, providing a novel access to sultams with up to 99% ee. Preliminary mechanistic insights revealed that the reaction proceeded through a N-O bond cleavage, dehydration, and the sequential asymmetric hydrogenation.

Catalytic enantioselective synthesis of 3-substituted benzosultams via Corey-Bakshi-Shibata reduction of cyclic N-sulfonylimines

The catalytic asymmetric synthesis of 3-substituted benzo-fused sultams employing the Corey-Bakshi-Shibata reduction with catecholborane of the corresponding cyclic N-sulfonylimines is reported. Good to excellent yields (74-95%) and enantiomeric excesses