4219-24-3Relevant articles and documents
Iridium-Catalyzed γ-Selective Hydroboration of γ-Substituted Allylic Amides
Zhao, Hongliang,Gao, Qian,Zhang, Yajuan,Zhang, Panke,Xu, Senmiao
supporting information, p. 2861 - 2866 (2020/04/02)
Reported here for the first time is the Ir-catalyzed γ-selective hydroboration of γ-substituted allylic amides under mild reaction conditions. A variety of functional groups could be compatible with reaction conditions, affording γ-branched amides in good yields with ≤97% γ-selectivity. We have also demonstrated that the obtained borylated products could be used in a series of C-O, C-F, C-Br, and C-C bond-forming reactions.
A practical copper-catalyzed approach to β-lactams: via radical carboamination of alkenyl carbonyl compounds
Shi, Peng,Wang, Jie,Gan, Zixu,Zhang, Jingyu,Zeng, Runsheng,Zhao, Yingsheng
supporting information, p. 10523 - 10526 (2019/09/06)
Functionalized β-lactams are highly important motifs in synthetic chemistry. We report an efficient and novel approach to the synthesis of β-lactams via a copper(i)-catalyzed cascade process involving C(benzyl)-H radical abstraction, intermolecular alkene addition, and intramolecular amination reaction. Variously substituted alkenes were synthesized from vinylacetic acid, leading to the corresponding β-lactams in moderate to good yields. Preliminary studies indicate that the reaction undergoes a free radical mechanism via a Cu(i)/Cu(ii)/Cu(iii) catalytic cycle.
Synthetic method for drug intermediate 3-alkenylhexanoic acid
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Paragraph 0018-0019, (2018/07/30)
The invention discloses a synthetic method for the drug intermediate 3-alkenylhexanoic acid. The synthetic method comprises the following steps: adding 2-bromo-3-hexen-1-one and 1.6 L of a potassium nitrate solution into a reaction vessel, controlling a stirring speed to be 110-130 rpm, maintaining a temperature at 30-36 DEG C, carrying out a reaction for 50-70 min, adding an isopropyl butyrate solution, raising a solution temperature to 40-45 DEG C and continuing the reaction for 1-2 h; and then adding molybdenum dichloride powder, controlling the stirring speed to be 220-250 rpm, carrying out a reaction for 60-90 min, then carrying out washing with a diethylene glycol monoethyl ether solution a plurality of times, then carrying out washing with a potassium bromide solution a plurality oftimes, adding a trichloroacetic acid solution to adjust the pH value to 4-5, carrying out extraction with a sulfolane solution a plurality of times, combining extracts, then carrying out washing witha bromoethane solution and a phenetole solution successively, carrying out recrystallization in a solution of N,N-dibutylaniline, and then carrying out dehydrating with a dehydrating agent to obtainthe finished 3-alkenylhexanoic acid.
