299434-13-2

Upstream product

• 629-03-8 1 ,6-dibromohexane 
• 183624-93-3 (3R,3aR,6R,6aR)-6-benzyloxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-ol 
• 4672-50-8 1,6-bis(p-toluenesulfonyloxy)hexane 
• 641-74-7 1,4:3,6-dianhydro-D-mannitol 
• 100-39-0 benzyl bromide 

Relevant academic research and scientific papers

Synthesis of New Diols Derived from Dianhydrohexitols Ethers under Microwave-Assisted Phase Transfer Catalysis

Alkylation of mono-benzylated isosorbide and isomannide was performed under microwave assisted phase transfer catalysis (PTC). A small amount of solvent was necessary to provide good yields (90-96%) within 15 min. In order to minimize the competitive elimination, halide leaving group was changed to tosylate as competitive S(N)2-E2 processes were involved. After removal of benzyl moiety by hydrogenation, a series of new diols from dianhydrohexitols were thus prepared. (C) 2000 Elsevier Science Ltd.