300-40-3

Basic information

• Product Name: 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol, (+)-tropate (ester), sulfate (2 :1) (salt)
• Synonyms: 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol, (+)-tropate (ester), sulfate (2 :1) (salt);1αH,5αH-Tropan-3a-ol, (+)-tropate (ester), sulfate (2:1) (8CI);Benzeneacetic acid, α-(hydroxymethyl)-, 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, [3(R)-endo]-, sulfate (2:1) (salt)
• CAS NO: 300-40-3
• Molecular Formula: C₁₇H₂₃NO₃*H₂O₄S
• Molecular Weight: 676.823
• Mol File: 300-40-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 429.8°Cat760mmHg
• Flash Point: 213.7°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 3.76E-08mmHg at 25°C
• CAS DataBase Reference: 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol, (+)-tropate (ester), sulfate (2 :1) (salt)(CAS DataBase Reference)
• NIST Chemistry Reference: 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol, (+)-tropate (ester), sulfate (2 :1) (salt)(300-40-3)
• EPA Substance Registry System: 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol, (+)-tropate (ester), sulfate (2 :1) (salt)(300-40-3)

Safety Data

• Hazardous Substances Data: 300-40-3(Hazardous Substances Data)

Usage

InChI:InChI=1/2C17H23NO3.H2O4S/c2*1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12;1-5(2,3)4/h2*2-6,13-16,19H,7-11H2,1H3;(H2,1,2,3,4)/t2*13?,14?,15?,16-;/m00./s1

Upstream product

• 51-55-8 Atropine 
• 101-41-7 benzeneacetic acid methyl ester 
• 103-82-2 phenylacetic acid 
• 103-80-0 phenylacetyl chloride 
• 55-48-1 L-hyoscyamine sulphate 
• 55-48-1 (1R,3r,5S)-3-tropoyloxytropanium sulfate 
• 120-29-6 3-tropanol 
• 532-24-1 tropinone 
• 542-05-2 acetonedicarboxylic acid 
• 59216-85-2 α-formyl phenyl acetic acid 

Downstream Products

• 120-29-6 3-tropanol 
• 13269-35-7 (+)-Atropine 
• 101-31-5 Hyoscyamine 
• 55-48-1 (1R,3r,5S)-3-tropoyloxytropanium sulfate 
• 55-48-1 L-hyoscyamine sulphate 
• 51-55-8 Atropine 
• 22226-37-5 α-formyl phenyl acetic acid tropine ester 
• 6835-16-1 (S)-atropine sulfate 
• 100-52-7 benzaldehyde 
• 16839-98-8 Noratropine 
• 510-25-8 β-Belladonnin 
• 16175-59-0 Apoatropin 
• 510-25-8 α-Belladonnin 
• 135-97-7 pseudotropine 

Relevant articles and documents

Enantiomeric separation and simulation study of eight anticholinergic drugs on an immobilized polysaccharide-based chiral stationary phase by HPLC

The enantiomeric separation of eight anticholinergic drugs was first systematically examined on a derivative polysaccharide chiral stationary phase (CSP), i.e. Chiralpak ID in the normal phase mode. Except for scopolamine hydrobromide and benzhexol hydroc

An anti-choline medicine preparation method of atropine sulfate

The invention provides a synchronizing method of atropine sulphate. The method is characterized in that hydrolyzing methyl phenoxyacetate (II) is hydrolyzed to obtain a compound (III); the compound (III) and thionyl chloride are subjected to acylation reaction to obtain a compound (IV); the compound (IV) and 8-methyl-8-azabicyclo[3.2.1]oct-3-alchol are subjected to condensation reaction to obtain a compound (V); the compound (V) and paraformaldehyde are used for producing atropine (VI) under an alkaline condition; the atropine (VI) is salified under an acidic condition to obtain the atropine sulphate (I). The preparation method is simple in technology, high in yield, high in purity, low in monomer impurity and easy for industrial production.