300862-09-3

Upstream product

• 1885-14-9 phenyl chloroformate 
• 540-37-4 p-aminoiodobenzene 
• 59-88-1 phenylhydrazine hydrochloride 
• 1122-85-6 phenyl cyanate 
• 15845-62-2 1-iodo-4-isocyanatobenzene 
• 108-95-2 phenol 
• 22693-31-8 azido(4-iodophenyl)methanone 

Downstream Products

• 628293-20-9 (R)-N-4-iodophenyl-N'-(1-methyl-2-hydroxy)ethylurea 
• 1041445-52-6 C₁₂H₁₈INO₂Si 
• 1577179-84-0 phenyl 4-(tributylstannyl)phenylcarbamate 
• 74558-13-7 1,3-dimethyl-2,4,6-trioxo-hexahydro-pyrimidine-5-carboxylic acid 4-iodo-anilide 
• 73469-90-6 C₇H₈IN₃O 

Relevant academic research and scientific papers

Structural Insights into Schistosoma mansoni Carbonic Anhydrase (SmCA) Inhibition by Selenoureido-Substituted Benzenesulfonamides

Tegumental carbonic anhydrase from the wormSchistosomamansoni(SmCA) is considered a new anti-parasitic target because suppressing its expression interferes with schistosome metabolism and virulence. Here, we present the inhibition profiles of selenoureido

Iodine-mediated aryl transfer reaction from arylhydrazine hydrochlorides to nitriles

An iodine-promoted, metal-, base-, and solvent-free cross-coupling reaction was developed for the synthesis of various useful secondary amides via an aryl N-addition reaction of aryl groups to cyano groups. This aryl transfer reaction proceeds with arylhydrazine hydrochlorides serving as the aryl donors. A labelling experiment shows that the N atom in the product comes from the cyano group of the nitriles, which are low in cost. A plausible radical-driven mechanism is also proposed.

Synthesis, characterization and photophysical studies of self-assembled azo biphenyl urea derivatives

We reported the synthesis of a new series of azobiphenyl based urea derivatives 7 and their stimulus-responsive supramolecular structures in the form of sheet like self-assembled formations. The self-assembled nanostructural formations of azo derivatives

CARBAMATE COMPOUNDS AND METHODS OF USE IN DISEASES OF THE NERVOUS SYSTEM

In general, among other things, compounds of Formula I are provided: or a pharmaceutically acceptable salt thereof, in which R1-7 9-10 are each independently selected from the group consisting of hydrogen, hydroxy, alkoxy, and alkyl; and R8 is selected from the group consisting of fluoro, iodo, and tributyltin. Other compounds are also provided. Methods of treatment and diagnosis are also provided.

Design and synthesis of novel triazole antifungal derivatives by structure-based bioisosterism

The incidence of life-threatening fungal infections is increasing dramatically. In an attempt to develop novel antifungal agents, our previously synthesized phenoxyalkylpiperazine triazole derivatives were used as lead structures for further optimization. By means of structure-based bioisosterism, triazolone was used as a new bioisostere of oxygen atom. This type of bioisosteric replacement can improve the water solubility without loss of hydrogen-bonding interaction with the target enzyme. A series of triazolone-containing triazoles were rationally designed and synthesized. As compared with fluconazole, several compounds showed higher antifungal activity with broader spectrum, suggesting their potential for further evaluations.

MONOACYLGLYCEROL LIPASE INHIBITORS FOR MODULATION OF CANNABINOID ACTIVITY

Disclosed are compounds and compositions that inhibit the action of monoacylglycerol lipase (MGL) and fatty acid amide hydrolase (FAAH), methods of inhibiting MGL and FAAH, methods of modulating cannabinoid receptors, and methods of treating various disorders related to the modulation of cannabinoid receptors.

One-pot synthesis of cyclic triamides with a triangular cavity from trans-stilbene and diphenylacetylene monomers

(Chemical Equation Presented) Base-promoted self-condensation reactions of trans-stilbene and diphenylacetylene monomers bearing 4-alkylamino and 4′-methoxycarbonyl groups were investigated. Reactions of N-propyl monomers under pseudohigh-dilution conditions (a THF solution of monomer was added dropwise to a THF solution of LiHMDS) afforded the corresponding cyclic triamides in good yields. X-ray crystallographic analysis showed that these cyclic triamides possessed an almost equilateral triangle structure with a cavity surrounded by tilted benzene rings.

HALOETHYL UREA COMPOUNDS AND THEIR USE TO ATTENUATE, INHIBIT OR PREVENT NON-CANCEROUS PATHOGENIC CELLULAR PROLIFERATION AND DISEASES ASSOCIATED THEREWITH

The present invention provides haloethyl urea compounds as described in Formula (I) and their use as anti-proliferative agent in the attenuation, inhibition, or prevention of non-cancerous cellular proliferation. These compounds are also provided for use as a therapeutic agent in the treatment of a disease or disorder, wherein pathogenesis of said disease or disorder is associated with non-cancerous pathogenic cellular proliferation.

HALOETHYL UREA COMPOUNDS AND THE USE THEREOF TO ATTENUATE, INHIBIT OR PREVENT CANCER CELL MIGRATION

The present invention provides haloethyl urea compounds as described in Formula (I) and their use as therapeutic agent in the attenuation, inhibition, or prevention of cancer cell migration and cancer cell proliferation.