30160-12-4

Basic information

• Product Name: 3-Quinolinecarboxylic acid, 2-phenyl-, ethyl ester
• CAS NO: 30160-12-4
• Molecular Formula: C18H15NO2
• Molecular Weight: 277.323
• Mol File: 30160-12-4.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: 3-Quinolinecarboxylic acid, 2-phenyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Quinolinecarboxylic acid, 2-phenyl-, ethyl ester(30160-12-4)
• EPA Substance Registry System: 3-Quinolinecarboxylic acid, 2-phenyl-, ethyl ester(30160-12-4)

Safety Data

• Hazardous Substances Data: 30160-12-4(Hazardous Substances Data)

Upstream product

• 552-89-6 2-nitro-benzaldehyde 
• 529-23-7 o-aminobenzaldehyde 
• 2216-94-6 phenylpropynoic acid ethyl ester 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 4403-69-4 2-amino-1-benzylamine 
• 13066-19-8 2-(2-phenylethenyl)benzenamine 
• 271-58-9 anthranil 
• 100-47-0 benzonitrile 
• 26260-02-6 2-iodobenzaldehyde 
• 33831-72-0 ethyl 3-amino-3-phenylprop-2-enoate 
• 100-52-7 benzaldehyde 
• 62-53-3 aniline 
• 538-51-2 benzylidene phenylamine 
• 623-47-2 propynoic acid ethyl ester 

Downstream Products

• 142849-37-4 4-Carboethoxy-3-phenyl-2-azabicyclo[4.4.0]decane 
• 1535966-39-2 (+)-ethyl 2-phenyl-1,2,3,4-tetrahydroquinoline-3-carboxylate 
• 94202-58-1 t-Boc-D-phenylalanyl-L-phenylalanine methyl ester 
• 871022-83-2 3-(thiomethyl)-S-(Boc-Gly-D-Phe)-2-phenylquinoline 
• 871022-81-0 3-(thiomethyl)-S-(Boc-D-Phe)-2-phenylquinoline 
• 871022-82-1 3-(thiomethyl)-S-(D-Phe)-2-phenylquinoline 
• 871022-80-9 3-(thiomethyl)-S-(Boc-Gly)-2-phenylquinoline 
• 871022-78-5 3-(thiomethyl)-S-acetyl-2-phenylquinoline 
• 871022-79-6 (2-phenylquinolin-3-yl)methanethiol 
• 871022-77-4 3-(hydroxymethyl)-2-phenylquinoline 
• 113387-33-0 phenyl-2 carbethoxy-3 dihydro-1,2 quinoleine 

Relevant articles and documents

Rawal's catalyst as an effective stimulant for the highly asymmetric Michael addition of β-keto esters to functionally rich nitro-olefins

A general approach to asymmetric synthesis of highly substituted dihydroquinolines was achieved through neighboring ortho-amino group engaged sequential Michael/amination/dehydration reactions on (E)-2-(2-nitrovinyl)anilines with cyclic and acyclic β-keto esters in the presence of a catalytic amount of Rawal's quinidine-NH-benzyl squaramide followed by TFA.

Quinoline derivative as well as preparation method and application thereof

The invention belongs to the technical field of chemical drug synthesis, and particularly relates to a quinoline derivative as well as a preparation method and application thereof. In a reaction system, firstly, a metal catalyst, a ligand and a silicon hydrogen reagent interact to generate metal hydride, the metal hydride and an alkyne compound are subjected to addition, the metal hydride and an anthranil compound are subjected to an electrophilic amination reaction, and then the polysubstituted quinoline derivative is obtained through intramolecular cyclization. According to the invention, the starting raw materials such as the alkyne and the anthranil compound of the reaction are cheap and easily available, a variety of different polysubstituted quinoline derivatives can be constructed by using the one-step method, and can be rapidly converted into other compounds through the oxidation, the reduction, the coupling and other approaches of the target molecule so as to provide the good application prospect in the fields of drug development and material preparation; and the method is mild in condition, green, efficient, simple to operate and very suitable for large-scale industrial production.

An efficient heterogeneous gold(I)-catalyzed intermolecular cycloaddition of 2-aminoaryl carbonyls and internal alkynes leading to polyfunctionalized quinolines

The first heterogeneous intermolecular cycloaddition of 2-aminoaryl carbonyls and internal alkynes was realized in DMF at 100 °C by using a triphenylphosphine-functionalized MCM-41-supported gold(I) complex [MCM-41-PPh3-AuCl] and AgOTf as catal