30168-33-3

Upstream product

• 532-27-4 1-chloroacetophenone 
• 18803-44-6 sodium p-chlorothiophenolate 
• 3226-37-7 4-chlorophenyl thiocyanate 
• 5633-34-1 (benzoylmethylene)dimethylsulfurane 
• 1142-19-4 4,4'-dichlorodiphenyl disulfide 
• 70-11-1 α-bromoacetophenone 
• 20718-17-6 2-(dimethyl(oxo)-λ⁶-sulfaneylidene)-1-phenylethan-1-one 
• 106-54-7 p-Chlorothiophenol 
• 98-88-4 benzoyl chloride 
• 6919-61-5 N-methoxy-N-methylbenzamide 
• 123-09-1 4-chlorophenyl methyl sulfide 
• 536-74-3 phenylacetylene 
• 16717-64-9 1-azidostyrene 
• 98-86-2 acetophenone 

Downstream Products

• 19968-36-6 5-(4-chloro-phenylsulfanyl)-4-phenyl-3H-thiazol-2-one 
• 17530-91-5 2-((4-chlorophenyl)sulfinyl)-1-phenylethan-1-one 
• 54720-50-2 2-bromo-2-(4-chloro-phenylsulfanyl)-1-phenyl-ethanone 
• 338794-35-7 2-(4-Chloro-phenylsulfanyl)-1-phenyl-ethanone oxime 
• 153235-46-2 7-(4-Chloro-phenylsulfanyl)-3-methyl-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine 
• 153235-47-3 7-(4-Chloro-phenylsulfanyl)-3-ethyl-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine 
• 153235-48-4 7-(4-Chloro-phenylsulfanyl)-3,6-diphenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine 
• 153235-49-5 7-(4-Chloro-phenylsulfanyl)-6-phenyl-3-p-tolyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine 
• 106-54-7 p-Chlorothiophenol 
• 1235497-54-7 4-(4-chlorophenyl)-5-[(4-chlorophenyl)sulfanyl]-2-methoxy-6-phenylnicotinonitrile 
• 1380501-91-6 methyl(4-chlorophenyl)sulfonium phenacylide 
• 1260255-00-2 2-[(4-chlorophenyl)sulfanyl]-1-phenyl-1-ethanone N-(Z)-2-[(4-chlorophenyl)sulfanyl]-1-phenylethylidenehydrazone 
• 1180676-96-3 ethyl (E)-4-(4-chlorophenoxy)-3-phenylbut-2-enoate 
• 187672-55-5 [4-(4-Chloro-phenylsulfanyl)-3-phenyl-isoxazol-5-yl]-acetic acid methyl ester 

Relevant academic research and scientific papers

An aryl thiol-vinyl azide coupling reaction and a thiol-vinyl azide coupling/cyclization cascade: efficient synthesis of β-ketosulfides and arene-fused 5-methylene-2-pyrrolidinone derivatives

The addition reaction of thiol to vinyl azide has been extensively studied. Variously substituted aryl thiols are all viable for this coupling process. The scope of the other partner is successfully expanded from α-aryl vinyl azide to α-alkyl vinyl azide.

Iridium-Catalyzed Carbenoid Insertion of Sulfoxonium Ylides for Synthesis of Quinoxalines and β-Keto Thioethers in Water

Sulfoxonium ylides as safe carbene precursors are described for iridium-catalyzed carbene insertions and annulation, providing a facile and green approach to access a variety of quinoxaline derivatives in water. This water-mediated method also allows the preparation of β-keto thioethers under mild condition.

Substituted α-Sulfur Methyl Carbanions: Effective Homologating Agents for the Chemoselective Preparation of β-Oxo Thioethers from Weinreb Amides

The proper generation of α-thiomethyllithium reagents via reductive lithiation or deprotonation followed by reaction with variously functionalized Weinreb amides represents an excellent method to access β-oxo thioethers. The procedure is adaptable to alky

KI/K 2 S 2 O 8 -Mediated α-C-H Sulfenylation of Carbonyl Compounds with (Hetero)Aryl Thiols

A new and facile KI/K 2 S 2 O 8 -mediated α-C-H sulfenylation of carbonyl compounds with (hetero)aryl thiols was developed for the formation of C-S bond at room temperature. This method provided a simple process for the sy

Catalyst-Free Difunctionalization of Activated Alkenes in Water: Efficient Synthesis of β-Keto Sulfides and Sulfones

Difunctionalization of activated alkenes, a powerful strategy in chemical synthesis, has been accomplished for direct synthesis of a series of β-keto sulfides and β-keto sulfones. The transformation, mediated by O2, proceeds smoothly in water and without any catalyst. Prominent advantages of this method include mild reaction conditions, purification simplicity, and gram-scale synthesis, underlining the practical utility of this methodology.

Catalyst-Free Insertion of Sulfoxonium Ylides into Aryl Thiols. A Direct Preparation of β-Keto Thioethers

Insertion of sulfoxonium ylides into the S-H bond of aryl thiols without the need for a catalyst is demonstrated, furnishing β-keto thioethers in excellent yield in most cases. The method overcomes traditional syntheses that employ metal catalysts in combination with diazo compounds or toxic and hard-prepared haloketones. The experimental setup consists of mixing the reagents in acetonitrile at room temperature. Additional experimental as well as kinetic isotopic effect studies give some insight into the mechanism of this reaction.

Copper-Catalyzed Synthesis of α-Thioaryl Carbonyl Compounds Through S-S and C-C Bond Cleavage

A method to access α-thioaryl ketones and α-thioaryl esters employing copper acetate (hydrate) as catalyst and readily accessible diaryl disulfides and β-diketones (or β-keto esters) has been developed. Both alkyl- and aryl-substituted carbonyl compounds can be prepared. Copyright

ALLOSTERIC PROTEIN KINASE MODULATORS

The invention provides specific small molecule compounds that allosterically regulate the activity or modulate protein-protein interactions of AGC protein kinases and the Aurora family of protein kinases, methods for their production, pharmaceutical compositions comprising same, and their use for preparing medicaments for the treatment and prevention of diseases related to abnormal activities of AGC protein kinases or of protein kinases of the Aurora family.

Gold-catalyzed carbene transfer to alkynes: Access to 2,4-disubstituted furans

Furans of gold: The first example of a gold-catalyzed intermolecular addition of carbon ylides to terminal alkynes is reported (see scheme; DCE=dichloroethane, Tf=trifluoromethanesulfonyl). Subsequent intramolecular trapping of the generated gold carbene completes a formal [3+2] cycloaddition, which represents a novel synthesis of 2,4-disubstituted furans. Copyright

Selective one-pot multicomponent synthesis and anti-tubercular evaluation of 5-(aryl/cyclohexylsulfanyl)-2-alkoxy-4,6-diarylnicotinonitriles

A new set of highly substituted pyridine derivatives has been synthesized by a product selective four component reaction of aryl aldehyde, malononitrile and 2-aryl/cyclohexylsulfanyl-1-aryl-1-ethanones in presence of sodium hydroxide in methyl/ethyl alcoh