30169-34-7

Basic information

• Product Name: Quinazoline, 6-chloro-2,4-diphenyl-
• CAS NO: 30169-34-7
• Molecular Formula: C20H13ClN2
• Molecular Weight: 316.79
• Mol File: 30169-34-7.mol
• Article Data: 34

Chemical Properties

• CAS DataBase Reference: Quinazoline, 6-chloro-2,4-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Quinazoline, 6-chloro-2,4-diphenyl-(30169-34-7)
• EPA Substance Registry System: Quinazoline, 6-chloro-2,4-diphenyl-(30169-34-7)

Safety Data

• Hazardous Substances Data: 30169-34-7(Hazardous Substances Data)

Upstream product

• 719-59-5 5-chloro-2-aminobenzophenone 
• 100-46-9 benzylamine 
• 103-82-2 phenylacetic acid 
• 100-52-7 benzaldehyde 
• 106-47-8 4-chloro-aniline 
• 928782-97-2 4-chloro-2-(phenylethynyl)aniline 
• 100-47-0 benzonitrile 
• 5922-60-1 2-amino-5-chlorobenzonitrile 
• 98-80-6 phenylboronic acid 
• 85-44-9 phthalic anhydride 
• 1073-70-7 4-chlorophenylhydrazine hydrochloride 
• 501-65-5 diphenyl acetylene 
• 68763-82-6 2-(4-chlorophenyl)-2,3-dihydrophthalazine-1,4-dione 
• 707-07-3 orthobenzoic acid trimethyl ester 

Relevant articles and documents

A convenient access to 2,4-disubstituted quinazolines via one-pot three-component reaction under mild conditions?

A new and practical method has been developed for the synthesis of 2,4-disubstituted quinolines via one-pot three-component reaction of o-amino arylketones, aldehydes and ammonium acetate in high yields by using DDQ in CH3CN under mild conditio

TMSOTf-catalyzed synthesis of substituted quinazolines using hexamethyldisilazane as a nitrogen source under neat and microwave irradiation conditions

In this article, we report an efficient and mild synthetic route for the construction of substituted quinazolines from functionalized 2-aminobenzophenones with various benzaldehydes usingcat. TMSOTf and hexamethyldisilazane (HMDS) under neat, metal-free and microwave irradiation conditions in which gaseous ammonia was formedin situ. This synthetic protocol provided the desired quinazolines with a broad substrate scope in good to excellent yields. Some structures were confirmed by X-ray single-crystal diffraction analysis.

Silver(II) oxide-mediated synthesis of 2,4-diarylquinazolines

A single-pot procedure for the synthesis of 2,4-diarylquinazolines is described which involves a silver oxide-mediated C–H activation/C–N bond formation process. The generality of this method with respect to substituent effects is presented along with studies leading to process optimization. Mechanistic investigations provide support for the involvement of radical intermediates in the reaction process.