30280-35-4

Usage

Uses

Used in Organic Synthesis:
N,N-Diethylglycine methyl ester is used as a reagent in organic synthesis for the preparation of various chemical compounds. Its role as a chiral building block is particularly valuable in this context, enabling the creation of enantiomerically pure products, which are essential in many chemical and pharmaceutical applications.
Used in Pharmaceutical Production:
In the pharmaceutical industry, N,N-Diethylglycine methyl ester is utilized in the production of drugs. Its chiral properties make it a key component in the synthesis of biologically active molecules, contributing to the development of new medications with improved efficacy and selectivity.
Used in Research and Development:
N,N-Diethylglycine methyl ester is also employed in research and development settings, where its unique properties are explored for potential applications in the creation of novel compounds and the advancement of synthetic methodologies. This includes its use in the synthesis of enantiomerically pure compounds, which is crucial for the study of stereochemistry and its implications in drug action and metabolism.

Upstream product

• 67-56-1 methanol 
• 6112-00-1 N,N-diethyl-2-diazoacetamide 
• 69762-72-7 <(Diethylamino)methylene>cyclohexane 
• 96-32-2 bromoacetic acid methyl ester 

Downstream Products

• 127218-65-9 2-Diethylamino-3-phenyl-succinic acid dimethyl ester 
• 127218-66-0 3-(Ethyl-methoxycarbonylmethyl-amino)-2-phenyl-butyric acid methyl ester 
• 55716-11-5 perfluoro(N-ethylmorpholine) 
• 758-48-5 perfluoro(N,N-diethylmethylamine) 
• 382-28-5 2,2,3,3,5,5,6,6-Octafluoro-4-trifluoromethyl-morpholine 
• 130159-30-7 perfluoro(N,N-diethylaminoacetyl fluoride) 
• 137-58-6 2-diethylamino-N-(2,6-dimethylphenyl)-acetamide 
• 3213-15-8 2-diethylamino-N-phenylacetamide 
• 1012918-35-2 2-(diethylamino)-N-(4-trifluoromethyl-phenyl)acetamide 
• 857570-37-7 2-(diethylamino)-N-(2,5-dimethyl-phenyl)acetamide 
• 72336-16-4 N-<(N',N'-diethylamino)acetyl>benzylamine 
• 584-39-4 2-(diethylamino)-N-(4-fluoro-2,6-dimethylphenyl)acetamide 
• 2644-33-9 2-(diethylamino)acetylhydrazide 

Relevant academic research and scientific papers

New indium-mediated reactions of enamines

New reactions of enamines were observed with allyl bromide or methyl bromoacetate in the presence of indium powder in THF, yielding respectively homoallylamines and β-aminoesters.

Substituent Effects on the Product Distribution in Diazo Amide Photochemistry. Role of Ground-State Conformational Populations

Effects of substituents on the photochemical processes of several α-diazo amides (1a-f) have been studied .Irradiation of 1b in ethyl ether and acetone afforded, in addition to a β-lactam, the reaction products with the solvents, ie., EtOCH2CONMe2 and 1,3-dioxolane, respectively, whereas similar irradiation of 1a in these solvents gave only intramolecular reaction products, ie., β- and γ-lactams.Displacement of oneof the alkyl groups on the amide nitrogen with a Ph group markedly changed its photochemical processes.Thus irradiations of 1c and 1d in MeOH gave oxindole almost exclusively.Introduction of an acetyl group on the diazo carbon also caused a change in the product distributions.Photolysis of 1e in methanol gave, for exaple, the Wolff rearrangement (WR) product of Me migration and a β-lactam, whereas similar irradiation of 1f afforded WR product and oxindole.The results are interpreted as indicating that the β-lactam, the oxindole, and the WR product are derived from the excited singlet state of s-Z form of the diazo amide itself, whereas that of s-E form dissociates nitrogen to generate singlet carbene, and that populations of each conformers in the ground state are important in determining the photochemical processes of the α-diazo amide.