30384-79-3

Basic information

• Product Name: 1H-Naphth[2,3-d]imidazole, 2-phenyl-
• CAS NO: 30384-79-3
• Molecular Formula: C17H12N2
• Molecular Weight: 244.296
• Mol File: 30384-79-3.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 1H-Naphth[2,3-d]imidazole, 2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Naphth[2,3-d]imidazole, 2-phenyl-(30384-79-3)
• EPA Substance Registry System: 1H-Naphth[2,3-d]imidazole, 2-phenyl-(30384-79-3)

Safety Data

• Hazardous Substances Data: 30384-79-3(Hazardous Substances Data)

Upstream product

• 109670-70-4 2-methyl-4-phenyl-3H-naphtho[2,3-b][1,4]diazepine 
• 7732-18-5 water 
• 771-97-1 2,3-Diaminonaphthalene 
• 65-85-0 benzoic acid 
• 100-46-9 benzylamine 
• 1608149-20-7 N²-benzylnaphthalene-2,3-diamine 
• 100-39-0 benzyl bromide 
• 100-52-7 benzaldehyde 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 31378-03-7 1-phenyl-2-tosylethanone 
• 873-67-6 benzonitrile oxide 
• 86255-33-6 N-(3-aminonaphthyl)benzamide oxime 
• 591-50-4 iodobenzene 
• 201230-82-2 carbon monoxide 

Relevant articles and documents

Anti-BVDV activity evaluation of naphthoimidazole derivatives compared with parental imidazoquinoline compounds

Background: Pestivirus genus includes animal pathogens which are involved in economic impact for the livestock industry. Among others, Bovine Viral Diarrhoea Virus (BVDV) establish a persistent infection in cattle causing a long list of symptoms and a high mortality rate. In the last decades, we synthesised and reported a certain number of anti-BVDV compounds. Methods: In them, imidazoquinoline derivatives turned out as the most active. Their mechanism of actions has been deeply investigated, BVDV RNA-dependent RNA polymerase (RpRd) resulted as target and the way of binding was predicted in silico through three main H-bond interaction with the target. The prediction could be confirmed by target or ligand mutation. The first approach has already been performed and published confirming the in silico prediction. Results: Here, we present how the ligand chemical modification affects the anti-BVDV activity. The designed compounds were synthesised and tested against BVDV as in silico assay negative control. Conclusion: The antiviral results confirmed the predicted mechanism of action, as the newly synthesised compounds resulted not active in the in vitro BVDV infection inhibition.

Synthesis of 2-arylbenzimidazole analogues

Substituted 2-arylbenzimidazoles (4) were easily synthesized in good yields starting from the condensation reaction of 1,2-diaminobenzenes (1) with β-ketosulfones (5) in the presence of boiling HOAc.

Copper-catalyzed synthesis of benzazoles via aerobic oxidative condensation of o-amino/mercaptan/hydroxyanilines with benzylamines

A simple and efficient method for the synthesis of benzazoles via Cu-catalyzed aerobic oxidative condensation of o-amino/mercaptan/hydroxyanilines with benzylamines was developed.