3048-12-2

Basic information

• Product Name: 1-nitro-4-(phenoxymethyl)benzene
• Synonyms: 1-Nitro-4-(phenoxymethyl)benzene; 4-Nitrobenzyl phenyl ether; benzene, 1-nitro-4-(phenoxymethyl)-
• CAS NO: 3048-12-2
• Molecular Formula: C₁₃H₁₁NO₃
• Molecular Weight: 229.2313
• Mol File: 3048-12-2.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 381.5°C at 760 mmHg
• Flash Point: 172.9°C
• Density: 1.232g/cm³
• Vapor Pressure: 1.11E-05mmHg at 25°C
• Refractive Index: 1.603
• CAS DataBase Reference: 1-nitro-4-(phenoxymethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-nitro-4-(phenoxymethyl)benzene(3048-12-2)
• EPA Substance Registry System: 1-nitro-4-(phenoxymethyl)benzene(3048-12-2)

Safety Data

• Hazardous Substances Data: 3048-12-2(Hazardous Substances Data)

Usage

General Description

1-nitro-4-(phenoxymethyl)benzene is a chemical compound with a molecular formula C13H11NO3. It is a nitro compound that contains a benzene ring with a nitro group at the 1 position and a phenoxymethyl group at the 4 position. The compound is commonly used in organic synthesis and as a precursor for the preparation of other organic compounds. It is also utilized in the manufacturing of dyes, polymers, and pharmaceuticals. 1-nitro-4-(phenoxymethyl)benzene is known to be potentially hazardous and should be handled with care, following proper safety procedures and guidelines.

Upstream product

• 619-73-8 4-nitrobenzyl chloride 
• 100-39-0 benzyl bromide 
• 4457-41-4 4-nitrobenzyl benzoate 
• 619-90-9 4-nitrobenzyl acetate 
• 930-68-7 cyclohexenone 
• 108-95-2 phenol 
• 100-44-7 benzyl chloride 
• 99-99-0 1-methyl-4-nitrobenzene 
• 139-02-6 sodium phenoxide 
• 100-14-1 4-nitrobenzyl chloride 
• 500-11-8 4-nitrobenzyl fluoride 
• 100-11-8 1-bromomethyl-4-nitro-benzene 

Downstream Products

• 881-67-4 4-nitrobenzaldehyde dimethyl acetal 
• 108-95-2 phenol 
• 619-50-1 4-nitrobenzoic acid methyl ester 
• 722536-19-8 (2-bromo-5-methoxyphenyl)[4-(4-nitrobenzyloxy)phenyl]methanone 
• 88089-57-0 3-Bromo-N-(4-phenoxymethyl-phenyl)-propionamide 
• 81461-87-2 N-(p-phenoxymethylphenyl)azetidinone 
• 81461-92-9 1-(4-Iodomethyl-phenyl)-azetidin-2-one 
• 21278-65-9 (4-Nitro-benzyl)-(4-fluorsulfonyl-phenyl)-aether 
• 950182-32-8 4-(4-nitrobenzyloxy)benzenesulfonyl chloride 
• 34512-33-9 4-nitrobenzaldehyde radical anion 
• 736-30-1 1,2-bis(4-nitrophenyl)ethane 
• 99-99-0 1-methyl-4-nitrobenzene 
• 619-93-2 4,4'-dinitro stilbene 
• 57181-90-5 phenyl 4-aminobenzyl ether 

Relevant articles and documents

KMnO4-catalyzed chemoselective deprotection of acetate and controllable deacetylation-oxidation in one pot

A novel and efficient protocol for chemoselective deacetylation under ambient conditions was developed using catalytic KMnO4. The stoichiometric use of KMnO4 highlighted the dual role of a heterogeneous oxidant enabling direct access to aromatic aldehydes in one-pot sequential deacetylation-oxidation. The reaction employed an alternative solvent system and allowed the clean transformation of benzyl acetate to sensitive aldehyde in a single step while preventing over-oxidation to acids. Use of inexpensive and readily accessible KMnO4 as an environmentally benign reagent and the ease of the reaction operation were particularly attractive, and enabled the controlled oxidation and facile cleavage of acetate in a preceding step. This journal is

Discovery of 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as new potent and selective human sirtuin 2 inhibitors

Human sirtuin 2 (SIRT2) plays pivotal roles in multiple biological processes such as cell cycle regulation, autophagy, immune and inflammatory responses. Dysregulation of SIRT2 was considered as a main aspect contributing to several human diseases, including cancer. Development of new potent and selective SIRT2 inhibitors is currently desirable, which may provide a new strategy for treatment of related diseases. Herein, a structure-based optimization approach led to new 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as SIRT2 inhibitors. SAR analyses with new synthesized derivatives revealed a number of new potent SIRT2 inhibitors, among which 28e is the most potent inhibitor with an IC50 value of 42?nM. The selectivity analyses found that 28e has a very good selectivity to SIRT2 over SIRT1 and SIRT3. In cellular assays, 28e showed a potent ability to inhibit human breast cancer cell line MCF-7 and increase the acetylation of α-tubulin in a dose-dependent manner. This study will aid further efforts to develop highly potent and selective SIRT2 inhibitors for the treatment of cancer and other related diseases.

Tetrabutyl ammonium bromide-mediated benzylation of phenols in water under mild condition

Benzylation of phenol was successfully achieved in water under room temperature mediated by tetrabutylammonium bromide (TBAB) for only 2 h affording the corresponding benzyl phenyl ether with good to excellent yields. This protocol is very efficient, simple, avoiding catalysts, easy to work-up after reaction, and especially 'green'.