3048-12-2

Basic information

• Product Name: 1-nitro-4-(phenoxymethyl)benzene
• Synonyms: 1-Nitro-4-(phenoxymethyl)benzene; 4-Nitrobenzyl phenyl ether; benzene, 1-nitro-4-(phenoxymethyl)-
• CAS NO: 3048-12-2
• Molecular Formula: C₁₃H₁₁NO₃
• Molecular Weight: 229.2313
• Mol File: 3048-12-2.mol

Chemical Properties

• Boiling Point: 381.5°C at 760 mmHg
• Flash Point: 172.9°C
• Density: 1.232g/cm³
• Vapor Pressure: 1.11E-05mmHg at 25°C
• Refractive Index: 1.603
• CAS DataBase Reference: 1-nitro-4-(phenoxymethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-nitro-4-(phenoxymethyl)benzene(3048-12-2)
• EPA Substance Registry System: 1-nitro-4-(phenoxymethyl)benzene(3048-12-2)

Safety Data

• Hazardous Substances Data: 3048-12-2(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
1-nitro-4-(phenoxymethyl)benzene is used as a precursor for the preparation of other organic compounds, facilitating the synthesis of various complex organic molecules.
Used in Dye Manufacturing:
1-nitro-4-(phenoxymethyl)benzene is used as a starting material in the production of dyes, contributing to the development of colorants for various applications.
Used in Polymer Production:
1-nitro-4-(phenoxymethyl)benzene is utilized in the manufacturing of polymers, playing a role in the creation of new materials with specific properties.
Used in Pharmaceutical Industry:
1-nitro-4-(phenoxymethyl)benzene is used as a building block in the synthesis of pharmaceuticals, aiding in the development of new drugs and medications.
Safety Note:
1-nitro-4-(phenoxymethyl)benzene is known to be potentially hazardous and should be handled with care, following proper safety procedures and guidelines.

Upstream product

• 500-11-8 4-nitrobenzyl fluoride 
• 139-02-6 sodium phenoxide 
• 100-14-1 4-nitrobenzyl chloride 
• 108-95-2 phenol 
• 619-73-8 4-nitrobenzyl chloride 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 
• 4457-41-4 4-nitrobenzyl benzoate 
• 619-90-9 4-nitrobenzyl acetate 
• 930-68-7 cyclohexenone 
• 99-99-0 1-methyl-4-nitrobenzene 
• 100-11-8 1-bromomethyl-4-nitro-benzene 

Downstream Products

• 4279-47-4 (2,4-dinitro-phenyl)-(4-nitro-benzyl)-ether 
• 81461-92-9 1-(4-Iodomethyl-phenyl)-azetidin-2-one 
• 81461-87-2 N-(p-phenoxymethylphenyl)azetidinone 
• 88089-57-0 3-Bromo-N-(4-phenoxymethyl-phenyl)-propionamide 
• 619-50-1 4-nitrobenzoic acid methyl ester 
• 108-95-2 phenol 
• 881-67-4 4-nitrobenzaldehyde dimethyl acetal 
• 722536-19-8 (2-bromo-5-methoxyphenyl)[4-(4-nitrobenzyloxy)phenyl]methanone 
• 21278-65-9 (4-Nitro-benzyl)-(4-fluorsulfonyl-phenyl)-aether 
• 950182-32-8 4-(4-nitrobenzyloxy)benzenesulfonyl chloride 
• 34512-33-9 4-nitrobenzaldehyde radical anion 
• 736-30-1 1,2-bis(4-nitrophenyl)ethane 
• 99-99-0 1-methyl-4-nitrobenzene 
• 619-93-2 4,4'-dinitro stilbene 

Relevant articles and documents

KMnO4-catalyzed chemoselective deprotection of acetate and controllable deacetylation-oxidation in one pot

A novel and efficient protocol for chemoselective deacetylation under ambient conditions was developed using catalytic KMnO4. The stoichiometric use of KMnO4 highlighted the dual role of a heterogeneous oxidant enabling direct access to aromatic aldehydes in one-pot sequential deacetylation-oxidation. The reaction employed an alternative solvent system and allowed the clean transformation of benzyl acetate to sensitive aldehyde in a single step while preventing over-oxidation to acids. Use of inexpensive and readily accessible KMnO4 as an environmentally benign reagent and the ease of the reaction operation were particularly attractive, and enabled the controlled oxidation and facile cleavage of acetate in a preceding step. This journal is

Static phase transfer catalysis for Williamson reactions: Pickering interfacial catalysis

Pickering interfacial catalysis (PIC) systems are regarded as an innovative platform for the design of efficient static biphasic catalytic reactions. In this study, a static PIC system with high catalytic activity was constructed for a phase transfer cata

Discovery of 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as new potent and selective human sirtuin 2 inhibitors

Human sirtuin 2 (SIRT2) plays pivotal roles in multiple biological processes such as cell cycle regulation, autophagy, immune and inflammatory responses. Dysregulation of SIRT2 was considered as a main aspect contributing to several human diseases, including cancer. Development of new potent and selective SIRT2 inhibitors is currently desirable, which may provide a new strategy for treatment of related diseases. Herein, a structure-based optimization approach led to new 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as SIRT2 inhibitors. SAR analyses with new synthesized derivatives revealed a number of new potent SIRT2 inhibitors, among which 28e is the most potent inhibitor with an IC50 value of 42?nM. The selectivity analyses found that 28e has a very good selectivity to SIRT2 over SIRT1 and SIRT3. In cellular assays, 28e showed a potent ability to inhibit human breast cancer cell line MCF-7 and increase the acetylation of α-tubulin in a dose-dependent manner. This study will aid further efforts to develop highly potent and selective SIRT2 inhibitors for the treatment of cancer and other related diseases.

N-(4-substituted phenyl)-2-substituted acetamide compound and is use as SIRT2 protein inhibitor

The invention discloses a compound shown in the formula I or its pharmaceutically acceptable salt, crystalline form and solvate. X represents a group shown in the description, Y represents a group shown in the description, R1, R2 and R3 independently represent H, hydroxyl, halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl or phenyl, and R4 represents aryl, heteroaryl, substituted aryl or substituted heteroaryl. The novel compound shown in the formula I has good inhibition activity to SIRT2 and tumors, has a good medicinal value and provides a novel potential choice for clinical medication.

Tetrabutyl ammonium bromide-mediated benzylation of phenols in water under mild condition

Benzylation of phenol was successfully achieved in water under room temperature mediated by tetrabutylammonium bromide (TBAB) for only 2 h affording the corresponding benzyl phenyl ether with good to excellent yields. This protocol is very efficient, simple, avoiding catalysts, easy to work-up after reaction, and especially 'green'.

Catalytic aerobic synthesis of aromatic ethers from non-aromatic precursors

Only little waste: Aryl ether formation is accomplished by oxidative condensation of alcohols and 2-cyclohexenones. The reaction complements the existing methods used by synthetic chemists to obtain aryl ethers, and allows a straightforward access to a wide range of functionalized products. In addition, the catalytic reaction with O2 as the oxidant generates water as the only by-product and provides a greener approach to aryl ethers. Copyright

A PEG1000-DAIL[CdCl3]-toluene temperature-dependent biphasic system that regulates homogeneously catalyzed C-O coupling of organic halides with phenols and alcohols under ligand-free conditions

An efficient, experimentally simple, and convenient procedure for the C-O coupling of organic halides with phenols and alcohols in a PEG 1000-DAIL[CdCl3]-toluene temperature-dependent biphasic system has been developed. The product can be easily isolated by a simple decantation, and the catalytic system can be recycled and reused without loss of catalytic activity.

Di-p-nitrobenzyl azodicarboxylate (DNAD): An alternative azo-reagent for the Mitsunobu reaction

Di-p-nitrobenzyl azodicarboxylate is prepared in 83.6% yield in two steps as a bright yellow solid, which can be used as an azo-reagent in the Mitsunobu reaction. When a chiral secondary alcohol was used, sufficient configurational inversion of alcohol occurred under Mitsunobu conditions. That the hydrazine produced from DNAD is semisoluble in some solvents such as THF and CH 2Cl2 makes it separated easily from the reaction mixture just via filtration. Then the recovered hydrazine compound can be re-exposed to oxidant to produce DNAD. Because DNAD is more stable than DIAD at ambient temperatures and allows easy separation, it is a good alternative azo-reagent for the Mitsunobu reaction.

Ionic liquids as reagent and reaction medium: Preparation of alkyl aryl ethers

Room temperature ionic liquid, [bmIm]OH, is used as a green recyclable reaction medium and reagent for the alkylation of phenols in excellent yields. The recovered ionic liquid was reused five to six times with consistent activity.

SELECTIVE ESTROGEN RECEPTOR MODULATORS

The present invention provides a compound represented by the following formula (I); [wherein T represents a single bond, a C1-C4 alkylene group which may have a substituent and the like; formula (I-1) represents a single bond or a double bond; A represents a single bond, a bivalent 5- to 14-membered heterocyclic group which may have a substituent and the like; Y represents a single bond and the like; Z represents a methylene group and the like; ring G represents a phenylene group and the like which may condense with a 5- to 6-membered ring and may have a heteroatom; Ra and Rb are the same as or different from each other and represent a hydrogen atom and the like; W represents a single bond and the like; R' represents 1 to 4 independent hydrogen atoms and the like; and R" represents 1 to 4 independent hydrogen atoms and the like] or a salt thereof, or a hydrate thereof.