881-67-4Relevant academic research and scientific papers
Synthesis of DPA-triazole structures and their application as ligand for metal catalyzed organic reactions
Colombo Dugoni, Greta,Sacchetti, Alessandro,Urra Mancilla, Carolina
, (2021/12/06)
In this work, the use of DPA-triazole (DPA = dipicolylamine) molecules as ligands for metal catalyzed organic reactions has been investigated. A small library of ligands has been prepared by a CuAAC (click reaction) between propargyl-DPA and different azi
Photochemical synthesis of acetals utilizing Schreiner's thiourea as the catalyst
Kokotos, Christoforos G.,Nikitas, Nikolaos F.,Spiliopoulou, Nikoleta
supporting information, p. 3539 - 3545 (2020/06/25)
Acetalization of aldehydes is an area of great importance in Organic Chemistry for both synthetic and biological puproses. Herein, we report a mild, inexpensive and green photochemical protocol, where Schreiner's thiourea (N,N′-bis[3,5-bis(trifluoromethyl)-phenyl]-thiourea) is utilized as the catalyst and cheap household lamps as the light source. A variety of aromatic and aliphatic aldehydes were converted into acetals in good to high yields (23 examples, 36-96% yield) and an example of the synthesis of a cyclic acetal is provided. The reaction mechanism was also studied.
Preparation method of acetal or ketal compound
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Paragraph 0021-0030, (2020/04/22)
The invention discloses a preparation method of an acetal or ketal compound. The preparation method comprises the following steps: oscillating aldehyde or ketone, alcohol and a catalyst at 60 DEG C, and carrying out post-treatment after the reaction is finished to obtain the acetal compound, wherein the catalyst comprises alpha-chymotrypsin, the aldehyde or ketone has a structure represented by acompound A, R1 and R2 are respectively and independently selected from aryl, H and alkyl, the alcohol has a structure represented by a compound B, and R3 is selected from saturated alkane. The preparation method provided by the invention is catalyzed by alpha-chymotrypsin, is mild in reaction condition, simple in operation process, low in cost and environment-friendly, and has popularization and application values.
α-Chymotrypsin-Induced Acetalization of Aldehydes and Ketones with Alcohols
Jiang, Guofang,Lan, Jin,Le, Zhanggao,Xie, Zongbo,Yang, Jiangnan,Zhu, Haibo
, p. 2121 - 2126 (2020/07/14)
This is the first report of a simple and general method for acetalization of aldehydes via an α-chymotrypsin-induced reaction under mild conditions. A broad range of aromatic and heteroaromatic aldehydes have been acetalized under neutral conditions in good yields using a catalytic amount of chymotrypsin.
Synthesis, structural determination and catalytic study of a new 2-D chloro-substituted zinc phosphate, (C8N2H20)[ZnCl(PO3(OH))]2
Rayes, Ali,Herrera, Raquel P,Moncer, Manel,Ara, Irene,Calestani, Gianluca,Ayed, Brahim,Mezzadri, Francesco
, (2019/11/03)
A novel chloro-substituted zinc-phosphate, (C8N2H20)[ZnCl(PO3(OH))], has been synthesized by a slow evaporation method in the presence of 1,3-cyclohexanebis- (methylamine), which acts as a template. The structure consists of vertex linked ZnO3Cl and PO3(OH) tetrahedral, assembled into corrugated porous layers [ZnCl(PO3(OH))2]∞ with (4.82) topology. The optical properties were also investigated using Diffuse Reflecting Spectroscopy (DRS), showing that the title compound has semiconducting properties. In addition, the catalytic activity of (C8N2H20)[ZnCl(PO3(OH))]2 has been tested in the acetalisation reaction of aldehydes. The title compound displayed a high catalytic activity with practically total conversion in many examples using MeOD as solvent and as the sole source of acetalisation. More importantly, the reaction crudes are very clean and only the preferred products are found in the NMR spectra.
FLUORESCENT PROBE FOR ALDH3A1 DETECTION
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Paragraph 0122, (2020/07/16)
[Problem to be Solved] To provide a fluorescent probe for ALDH3A1 detection that can be used in flow cytometry adaptable to live cells. [Means of Resolution] A compound represented by general formula (I) or a salt thereof, wherein the compound or salt the
Nickel-Catalyzed Chemoselective Acetalization of Aldehydes With Alcohols under Neutral Conditions
Subaramanian, Murugan,Landge, Vinod G.,Mondal, Akash,Gupta, Virendrakumar,Balaraman, Ekambaram
supporting information, p. 4557 - 4562 (2019/08/30)
A molecularly defined NiII-complex catalyzing the chemoselective acetalization of aldehydes with alcohols under neutral conditions is reported. The reaction is general, efficient and showed a wide substrate scope (including aliphatic aldehydes) as well as excellent functional group tolerance. Reusability of the present nickel catalyst is also demonstrated.
Photo-organocatalytic synthesis of acetals from aldehydes
Nikitas, Nikolaos F.,Triandafillidi, Ierasia,Kokotos, Christoforos G.
supporting information, p. 669 - 674 (2019/02/14)
A mild and green photo-organocatalytic protocol for the highly efficient acetalization of aldehydes has been developed. Utilizing thioxanthenone as the photocatalyst and inexpensive household lamps as the light source, a variety of aromatic and aliphatic aldehydes have been converted into acyclic and cyclic acetals in high yields. The reaction mechanism was extensively studied.
Acid properties of organosiliceous hybrid materials based on pendant (fluoro)aryl-sulfonic groups through a spectroscopic study with probe molecules
Erigoni, Andrea,Paul, Geo,Meazza, Marta,Hernández-Soto, María Consuelo,Miletto, Ivana,Rios, Ramon,Segarra, Candela,Marchese, Leonardo,Raja, Robert,Rey, Fernando,Gianotti, Enrica,Díaz, Urbano
, p. 6308 - 6317 (2019/11/20)
Two different heterogeneous catalysts carrying aryl-sulfonic moieties, in which the aromatic ring was either fluorinated or not, were successfully synthesized. The multi-step synthetic approaches implemented involved the synthesis of the silyl-derivative, template-free one-pot co-condensation (at low temperature and neutral pH) and tethering reaction. A multi-technique approach was implemented to characterize the hybrid organic-inorganic catalysts involving TGA, N2 physisorption analysis, FTIR spectroscopy, and ss MAS NMR (1H, 13C, 29Si) spectroscopy. Specifically, the acidity of the organosiliceous hybrid materials was studied through the adsorption of probe molecules (i.e. CO at 77 K and NH3 and TMPO at room temperature) and a combination of FTIR and ss MAS NMR spectroscopy. The catalytic activity of the two hybrids was tested in the acetal formation reaction between benzaldehyde and ethylene glycol. Preliminary results indicated superior performances for the fluoro-aryl-sulfonic acid, compared to the non-fluorinated sample. The findings hereby reported open new avenues for the design of heterogeneous sulfonic acids with superior reactivity in acid-catalyzed reactions. Moreover, through the implementation of spectroscopic studies, using probe molecules, it was possible to investigate in detail the acidic properties of hybrid organosiliceous materials.
Remote ‘Imidazole’ Based Ruthenium(II) p-Cymene Precatalyst for Selective Oxidative Cleavage of C?C Multiple Bonds
Dutta, Manali,Bania, Kusum Kumar,Pratihar, Sanjay
, p. 2683 - 2694 (2019/05/24)
The dual role of remote ‘imidazole’ attached with the precatalyst [(p-cymene)RuII(L)Y]+ (L=2-(4-substituted-phenyl)-1H-imidazo[4,5-f][1,10] phenanthroline, Y=chloride/solvent) was explored for the selective oxidative cleavage of C?C multiple bonds to acetals/aldehydes. The presence of ‘imidazole’ in the precatalysts was found to be useful for the activation of oxidant and release of p-cymene from the precatalysts, which in turn was not effective without the ‘imidazole’ moiety. The mechanistic aspects of the precatalyst were evaluated from spectroscopic, kinetic, and few other controlled experiments. The loss of p-cymene is the key step for the reaction and found to be faster in solvated precatalyst, [(p-cymene)RuII(L)(MeOH)]++ and thus showed 3–4-fold more effective as compared to [(p-cymene)RuII(L)Cl]+.
