30506-33-3

Upstream product

• 74-96-4 ethyl bromide 
• 54166-35-7 NaSph-4-Cme₃ 
• 15084-51-2 4-tert-butylbenzenesulfonyl chloride 
• 97-93-8 triethylaluminum 
• 93-89-0 benzoic acid ethyl ester 
• 35779-04-5 1-tert-butyl-4-iodobenzene 
• 75-03-6 ethyl iodide 
• 2396-68-1 4-t-butylbenzenethiol 
• 383-63-1 ethyl trifluoroacetate, 
• 3972-65-4 1-bromo-4-tert-butylbenzene 
• 75-08-1 ethanethiol 

Downstream Products

• 34545-14-7 Ethyl 4-tert-Butylphenyl Sulfone 
• 32672-41-6 Ethyl 4-tert-Butylphenyl Sulfoxide 
• 74-85-1 ethene 
• 85609-03-6 phenyl p-(tert-butyl)phenyl sulfide 

Relevant academic research and scientific papers

Thioether ligand-enabled cationic palladium (II)-catalyzed electrophilic C-H arylation of α,β-unsaturated oxime ethers

The use of the cationic palladium(II) catalyst realized electrophilic C-H arylation of α,β-unsaturated O-SEM oximes with arylboronic acids. This Pd-catalyzed electrophilic C-H arylation is facilitated by employing alkyl aryl thioether ligands, and optimization of the ligand structure greatly improves the yield. The resulting α,β-unsaturated oximes would provide access to multisubstituted heterocyclic compounds.

Copper-Catalyzed Three-Component Coupling Reaction of Aryl Iodides, a Disilathiane, and Alkyl Benzoates Leading to a One-Pot Synthesis of Alkyl Aryl Sulfides

A copper-catalyzed three-component coupling reaction of aryl iodides, hexamethyldisilathiane and alkyl benzoates leading to alkyl aryl sulfides has been demonstrated. A disilathiane acted as both a sulfur source and a promoter of the sulfidation, and the alkyl moiety of the alkyl benzoate was effectively introduced on one side of the sulfide. Moreover, we found that the protocol can be expanded to the preparation of ethyl phenyl selenide with diphenyl diselenide.

Microwave-assisted synthesis method for ethylation reaction

The invention relates to a microwave-assisted synthesis method for an ethylation reaction. The method is characterized in that a reaction substrate is in an organic solvent, trifluoroacetic acid ethyl ester is taken as an ethylation reagent, in the presence of an alkali, microwave-assisted heating is carried out for 2 minutes, and a corresponding ethylation product can be obtained. The invention provides a new method for the ethylation reaction. The reaction rate of the method is several times higher than that of a traditional method, the operation is simple and convenient, the cost is low, the reaction time is short, the application range of the substrate is wide, the use of the expensive or hypertoxic ethylation reagent can also be avoided, and the method has higher application value.

Pd2(dba)3/Xantphos-catalyzed cross-coupling of thiols and aryl bromides/triflates

The cross-coupling of aliphatic and aromatic thiols and aryl bromides/triflates mediated by a Pd2(dba)3/Xantphos catalytic system in refluxing xylene (140°C) affords the corresponding aryl thioethers in good to excellent yields.

PREPARATION OF PHENYL ARYL SULFIDES BY REACTION OF BENZYNE WITH ETHYL ARYL SULFIDES

A variety of ethyl aryl sulfides (1) react with benzyne, with evolution of ethylene, to give phenyl aryl sulfides (3) in excellent yields, thus providing a general synthesis of 3 from arenethiols since 1 are quantitatively obtainable from arenethiols and ethyl bromide.