30506-35-5Relevant articles and documents
The remarkable effect of methanol on sulfide photooxidations. Evidence for its dual reactivity
Clennan, Edward L.,Yang, Kang
, p. 1697 - 1700 (1993)
The addition of small amounts of methanol to photooxidation mixtures of sulfides dramatically enhances sulfone in preference to sulfoxide formation. High concentrations of methanol on the other hand have the opposite effect of promoting sulfoxide in prefe
Synthesis and reactions of exo-camphorylsulfonyloxaziridine
Davis, Franklin A.,Reddy, Rajarathnam E.,Kasu, Parimala V. N.,Portonovo, Padma S.,Carroll, Patrick J.
, p. 3625 - 3630 (1997)
The first example of an exo-camphorylsulfonyloxaziridine 4a was prepared by m-CPBA oxidation of camphor imine 9. This surprising result is due to the conformation of the imine which apparently prevents attack of the peracid from the endo direction. Simila
Development of a simple high-throughput assay for directed evolution of enantioselective sulfoxide reductases
Tarallo, Vincenzo,Sudarshan, Kasireddy,Nosek, Vladimír,Mí?ek, Jirí
supporting information, p. 5386 - 5388 (2020/06/04)
We report on the development of high-throughput fluorogenic assay that can streamline directed evolution of enantioselective sulfoxide reductases. As a model, methionine sulfoxide reductase A (MsrA) has been evolved to expand its limited substrate scope. The resulting mutant MsrA can resolve a range of new challenging racemic sulfoxides with high efficiency including the pharmaceutically relevant albendazole sulfoxide. The simplicity and the level of throughput make this method also suitable for the screening of metagenomic libraries in future for the discovery of new enzymes with similar reactivities.
Sulfoxide and sulfone compounds, as well as selective synthesis method and application thereof
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Paragraph 0045-0048, (2019/12/02)
The invention discloses a method for selectively synthesizing a sulfoxide compound shown as a formula (II) and a sulfone compound shown as a formula (III). In a reaction solvent, thioether (I) is usedas a reaction raw material and oxygen as an oxidation reagent, under the catalytic action of visible light and a photosensitive reagent; under the assistance of an additive, when a large-polarity proton-containing additive such as an acid and an alcohol or a solvent or an additive with excellent electron donating ability is used, a sulfoxide compound (II) is selectively generated; and when a small-polarity aprotic additive or a solvent is used, a sulfone compound (III) is selectively generated. The synthesis method has the advantages of easily available and cheap raw materials, simple reaction operation, mild reaction conditions, high yield and excellent functional group tolerance. According to the invention, synthesis and modification of some medicines are realized, and an efficient method for selectively constructing sulfoxide and sulfone compounds is provided for medicinal chemistry research.