30594-37-7

Basic information

• Product Name: dimethyl 1,2,6-trimethyl-4-(4-methoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• Synonyms: dimethyl 1,2,6-trimethyl-4-(4-methoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• CAS NO: 30594-37-7
• Molecular Weight: 345.395
• Mol File: 30594-37-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: dimethyl 1,2,6-trimethyl-4-(4-methoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl 1,2,6-trimethyl-4-(4-methoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylate(30594-37-7)
• EPA Substance Registry System: dimethyl 1,2,6-trimethyl-4-(4-methoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylate(30594-37-7)

Safety Data

• Hazardous Substances Data: 30594-37-7(Hazardous Substances Data)

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 105-45-3 acetoacetic acid methyl ester 
• 73257-47-3 1,4-dihydro-2,6-dimethyl-4-(p-methoxyphenyl)pyridine-3,5-dicarboxylic acid dimethyl ester 
• 74-88-4 methyl iodide 
• 74-89-5 methylamine 
• 23326-27-4 Methyl 2-butynoate 

Downstream Products

• 1451495-86-5 C₁₉H₂₂NO₅⁽¹⁺⁾ 

Relevant articles and documents

1,4-Dihydropyridine Cationic Peptidomimetics with Antibacterial Activity

We synthesized new broad spectrum antibacterial cationic peptidomimetics centered on a hydrophobic 1,4-dihydropyridine (1,4-DHP) scaffold. The synthesis involves the preparation of the scaffold in a three step Hantzsch reaction followed by simultaneous coupling of the 1,4-DHP scaffold to two dipeptides bearing cationic side chains. The synthesized peptidomimetics were found to have no measurable toxic hemolytic effect against mammalian red blood cells. The compounds were found to have antibacterial activity against Gram-(-) and Gram-(+) bacteria with MICs in the range of 35-100 μg/mL. These cationic antimicrobial peptidomimetics will lead to more effective antibacterial drug candidates based on a synthetically accessible scaffold.

Gold-catalyzed multicomponent reaction: Facile strategy for the synthesis of N-substituted 1,4-dihydropyridines by using activated alkynes, aldehydes, and methanamine

A convenient and efficient gold-catalyzed multicomponent reaction was developed for the synthesis of a wide range of N-substituted 1,4-dihydropyridines, which are found in a variety of bioactive compounds. This process proceeds smoothly under mild conditions with the use of commercially available substrates and affords the desired products in good to excellent yields. This method provides a highly efficient synthetic route to N-substituted 1,4-dihydropyridines from activated alkynes, aldehydes, and methanamine for which catalytic approaches are scarce. A facile gold-catalyzed strategy for the synthesis of N-substituted 1,4-dihydropyridines is developed through the multicomponent reaction of activated alkynes, aldehydes, and methanamine. The reaction is conducted under convenient conditions and affords the desired compounds in good to excellent yields. Copyright