dimethyl 1,2,6-trimethyl-4-(4-methoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Base Information

Chemical Name:dimethyl 1,2,6-trimethyl-4-(4-methoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS No.:30594-37-7
Molecular Formula:C₁₉H₂₃NO₅
Molecular Weight:345.395
Hs Code.:

Synonyms:dimethyl 1,2,6-trimethyl-4-(4-methoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylate

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Chemical Property of dimethyl 1,2,6-trimethyl-4-(4-methoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylate

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Technology Process of dimethyl 1,2,6-trimethyl-4-(4-methoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylate

There total 5 articles about dimethyl 1,2,6-trimethyl-4-(4-methoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 123-11-5
4-methoxy-benzaldehyde

: 74-89-5
methylamine

: 23326-27-4
Methyl 2-butynoate

: 30594-37-7
dimethyl 1,2,6-trimethyl-4-(4-methoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: With (triphenylphosphine)gold(I) chloride; silver trifluoromethanesulfonate; potassium hydrogencarbonate; In 1,4-dioxane; at 100 ℃; for 12h;
DOI:10.1002/ejoc.201301203

Reference yield:

: 73257-47-3
1,4-dihydro-2,6-dimethyl-4-(p-methoxyphenyl)pyridine-3,5-dicarboxylic acid dimethyl ester

: 74-88-4
methyl iodide

: 30594-37-7
dimethyl 1,2,6-trimethyl-4-(4-methoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1007/s10989-015-9460-1

Reference yield:

: 105-45-3
acetoacetic acid methyl ester

: 30594-37-7
dimethyl 1,2,6-trimethyl-4-(4-methoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium hydroxide / methanol / 7 h / Reflux

2: potassium hydroxide / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

With ammonium hydroxide; potassium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1007/s10989-015-9460-1